摘要
异基因造血干细胞移植包括已广泛开展的异基因骨髓移植 (Allo BMT) ,异基因外周血干细胞移植 (Allo PBSCT)以及脐带血造血干细胞移植 (CBT)。它是治愈血液系统恶性肿瘤和其它多种疾病的有效手段。移植后在造血系统恢复的同时 ,免疫系统也在经历一个重建过程 ,T细胞再生通过胸腺依赖途径和胸腺非依赖途径。成人由于胸腺功能退化 ,T细胞再生更多是靠成熟T细胞的外周扩增和胸腺外分化 ,造成T细胞库多样性受限 ,T细胞功能缺陷。因此 ,如何保护残存胸腺功能 ,促进T细胞胸腺内发育都是急待解决的问题。T细胞活化是移植物抗宿主病 (GVHD)发生的中心环节 ,通过免疫耐受的诱导使异基因抗原反应性T细胞失活 。
Allogeneic hematopoietic stem cell transplantation is curative therapy for many malignant hematologic and genetic disorders. The pathways by which T cell are regenerated in vivo are of central importance for host immune competence after the transplantation. Thymic-dependent and thymic-independent pathways of T-cell regeneration are primarily determined by thymus function, and that thymic-independent pathways are generally inadequate for restoration of host immunocompetence. T cell regeneration of adult recipients is largely through thymic-independent pathways due to reduced thymic regeneration capacity, resulting in quantitative defficiencies in T-cell number and severe restriction in the diversity of the regenerated T-cell receptor (TCR) repertoire. New strategies to enhance thymic function in man after BMT would hold great therapeutic potential. Activation of donor T cells is the cause of GVHD, the induction of anergy can inactivate specific sets of alloreactive T cells in the donor stem cells, which can prevent GVHD without inhibiting the entire T-cell repertoire.
出处
《中国实验血液学杂志》
CAS
CSCD
2000年第3期231-235,共5页
Journal of Experimental Hematology
关键词
异基因造血干细胞移植
T细胞
再生
免疫重建
allogeneic hematopoietic stem cell transplantationT-cell regenerationT-cell developmentimmune reconstitutionimmune tolerance
