摘要
目的 :探讨丹参酮对绝经后妇女冠心病 (CHD)的保护作用。方法 :选 138例绝经后 CHD患者 ,随机分为对照组、尼尔雌醇组和丹参酮组 ,分别给予安慰剂 (2片·月- 1 ·次 - 1 ) ,尼尔雌醇 (2 mg·月- 1 ·次 - 1 )及丹参酮 (3片 /次 ,每日 2次 ) ,6个月。分别于 0、 3、 6个月末抽血测血清雌二醇 (E2 )、一氧化氮 (NO)及低密度脂蛋白胆固醇 (L DL - C)水平。结果 :治疗前 3组患者 E2 水平 ,不存在差异 ;干预治疗 6个月后 ,1尼尔雌醇组和丹参酮组 E2水平均升高显著 (P<0 .0 1) ;2尼尔雌醇组和丹参酮组血清 NO含量均增高显著 (P<0 .0 1,P<0 .0 0 1) ;3丹参酮组 L DL - L水平显著下降 ,尼尔雌醇组的亦有下降 (P<0 .0 1,P<0 .0 5 )。结论
Objective:To study the protective mechanism of danshentong in post\|menopausal women with coronary heart disease(CHD).Methods:Choose 137 patients with CHD and divided into placebo,danshentong,nilestriol group randomly,serum estradiol(E 2),nitric oxide(NO) and low\|density lipoprotein cholesterol(LDL\|C) levels were measured at o,3rd and 6th month of treatment.Results:Before treatment E 2 levels of 3 groups was no difference( P >0 05);After 6 months treatment;①E 2 level increased in danshentong and nilestriol group( P <0 01, P <0 001),NO level increased in danshentong and nilesriol group( P <0 01, P <0 001);LDL level decreased significantly( P <0 01, P <0 05).Conclusion:Compared with nilestriol,danshentong has better protective effects in post\|menopausal women with CHD. Author′s address Affiliated Hospital of Binzhou Medical Colledge,Binzhou,Shandong,256603
出处
《心血管康复医学杂志》
CAS
2000年第4期28-30,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
丹参酮
雌二醇
一氧化氮
低密度脂蛋白
冠心病
Danshentong
Estradiol
Nitric oxide
Low-density lipoprotein
Coronary heart disease
