摘要
目的 :观察恩丹西酮和胃复安分别联用地塞米松控制化疗所致的胃肠道反应的疗效。方法 :对 68例接受阿霉素、顺铂化疗患者随机分组 ,恩丹西酮组 ,联合化疗前静点地塞米松 10mg ,静注恩丹西酮 8mg ;胃复安组联合化疗前地塞米松 10mg静点 ,胃复安 3 0mg化疗前后肌注。结果 :恩丹西酮联用地塞米松对化疗所致的急性呕吐及恶心的有效率分别为 85 3 %、88 2 4% ,明显优于胃复安联用地塞米松组。 (P <0 0 0 1,P <0 0 5 )。结论 :恩丹西酮联用地塞米松对阿霉素、顺铂引起的胃肠道反应的治疗具有协同作用 。
Objective To observe the therapeutic effects of ondansetron hydrochbride or metoclopramide dihydrochloride injection in combination with dexamethasone solium phosphate injection in gastrointestinal reactions caused by chemotherapy.Methods There were two groups,ondansetron hydrochloride group and metoclopramide dihydrochloride injection group.The former was given dexamethasone solium phosphate injection 10 mg by intravenous drip and ondansetron hydrochloride 8 mg by intravenous injection before combined chemotherapy;the latter was given dexamethason solium phosphate injection 10 mg by intravenous drip before combined chemotherapy and metoclopramide dihydrochloride injection 30 mg by intramuscular injection before and after chemotherapy.Results The effective rates of the first group were 853 % and 88 24 %,respectively.The therapeutic effects of the first group were significantly better than those of the second.(P<00001,P<005).Conclusion Ondansetron hydrochloride in combination with dexamethsone solium phosphate injection has synergistic action in treating gastrointestinal reactions caused by adramycin and platinum dichlorodiamine,and the former therapy was significantly better than the latter therapy.
出处
《山西职工医学院学报》
2000年第1期18-19,共2页
Journal of Shanxi Medical College for Continuing Education
关键词
胃肠道
联合化疗
止吐药
恩丹西酮
地塞米松
gastrointestinal tract
combined chemotherapy
ondansetron hydrochloride
