摘要
目的 :研究氯沙坦对高血压患者血压及血浆内皮素的影响情况。方法 :用特异性放射免疫分析法测定 30例原发性高血压 (EH)患者和 30例正常人的血浆内皮素 (ET) ,同时对 30例原发性高血压患者用氯沙坦 50mgQd连续治疗 2个月。结果显示 :EH患者的ET水平明显高于对照组 ,氯沙坦降压的同时可明显降低血浆内皮素 ,收缩压与ET呈正相关关系 (r =0 .56 )。结论 :氯沙坦降压的同时可改善内皮细胞 (VEC)的功能。
Objective: To observe the effect of Losartan on plasma endothelin(ET) in patients with essential hypertension. Methods: The concentration of plasma ET was measured by radioimmunoassay in 30 cases with essential hypertension before and after the treatment with Losartan 50mg per day for about two months and compared with that of 30 normal controls.Results: Plasma ET concentration in patients with essential hypertension was significantly higher than that of the normal subjects ( P <0.05). Losartan could significantly reduce the concentration of plasma ET.There was a positive relation between SBP and ET( r =0.56). Conclusion: Losartan has beneficial effects on lowering blood pressure as well as ameliorating the function of endothelial cells.
出处
《广州医学院学报》
2000年第3期19-21,共3页
Academic Journal of Guangzhou Medical College
关键词
氯沙坦
高血压
内皮素
Losartan
Hypetension
Endothelin
