摘要
目的:探讨大肠癌患者手术前后外周血淋巴细胞杀伤活性及诱导细胞因子能力的变化。方法:选择25例在本科进行大肠癌手术的病例,研究大肠癌患者手术前后NK、ADCC活性、T细胞亚群以及外周血淋巴细胞诱导IL—2水平的改变。结果:大肠癌患者手术后,NK、ADCE活性、CD4^+T细胞的比例及诱导IL—2的水平明显高于手术前(P<0.05),但与对照组相比,仍相差非常显著(P<0.01);按病期、病理分类比较发现,Dukes’AB期及高、中分化组淋巴细胞的功能抑制较CD组及低分化组轻(P<0.05)结论:大肠癌患者淋巴细胞活性的抑制与肿瘤的分期有关;大肠癌细胞可能分泌某些因子抑制免疫细胞的活性。
Objective:To investigate the changes of the cytotoxicity and cytokine expression of lymphocytes in the patient with colorectal cancer. Methods:25 cases of colorectal cancer were collected to detect the NK, ADCC activity, the porporation of CD4+ T, CD8+ T cell subtype and IL - 2 level induced in peripheral lymphocytes.Results: After operation, the NK, ADCC activity, the porporation of CD4 + T subtype and IL- 2 level induced were markedly improved compared with that in patient before operation , but in was still significant difference compared with the control group. Analysis its change pathologically, it was found that the functional suppression of lymphocyte in Dukes' AB stage or high differentiation were more mild than that in Dukes' C、D stage or low differentiation.Conclusion:The activity suppression of lymphocytes in the patient with colorectal cancer are significantly related to the course and pathological type of the cancer. Those results also suggest that colorectal carcinoma cell could secrete some factors to inhibit the activity of the lymphocyte in the patient.
出处
《临床肿瘤学杂志》
CAS
2000年第3期161-164,共4页
Chinese Clinical Oncology
关键词
大肠癌
杀伤活性
淋巴细胞
细胞因子
Colorectal carcinoma Cytotoxicity Lymphocyte Cytokine
