摘要
目的探讨高同型半胱氨酸血症在妊娠期高血压疾病,妊娠期糖尿病发病中的意义。方法分别检测妊娠期糖尿病(gestational diabetes mellitus,GDM)患者120例,妊娠期高血压疾病(hypertensive disorder complicating pregnancy,HDP)患者100例和正常妊娠妇女120例的血浆同型半胱氨酸浓度,并追踪三组不良妊娠结局发生情况。结果 GDM组、HDP组、正常孕妇组患者血浆同型半胱氨酸的浓度比较,差异有统计学意义(P<0.05);追踪GDM组、HDP组、正常孕妇组妊娠不良结局发生率,包括死胎、胎儿畸形、胎儿窘迫、新生儿窒息,差异有统计学意义(P<0.05)。结论妊娠期糖尿病患者及妊娠期高血压疾病患者血浆同型半胱氨酸浓度升高可能与胰岛素抵抗有关,同型半胱氨酸升高并非导致妊娠不良结局的独立因素。
Objective To investigate the significance ofhyperhomocysteinaemia in pathogenesis of hypertensive disorder complicating pregnancy and gestational diabetes mellitus. Methods The level of serum homocysteine in 120 cases of normal pregnancy women, 100 cases of women with hypertensive disorder complicating pregnancy, and 120 cases of women with gestational diabetes mellitus were detected. The adverse pregnancy outcomes were also analyzed in three groups. Results The serum homocysteine levels had significant statistical difference in three groups （P 〈0.05）. The incidence rates of adverse pregnancy outcomes, including fetal death, fetal malformation, fetal distress, and neonatal asphyxia were followed up in the three groups, which showed statistical difference （P 〈0.05）. Conclusions The increased level of serum homocysteine may be connected with insulin resistance between hypertensive disorder complicating pregnancy and gestational diabetes mellitus patients, but it is not an independent factor leading to adverse pregnancy outcomes.
出处
《临床医学工程》
2013年第7期806-808,共3页
Clinical Medicine & Engineering
关键词
妊娠
同型半胱氨酸
糖尿病
高血压
Pregnancy
Homocysteine
Diabetes mellitus
Hypertension
