摘要
目的探讨恶性胸液中葡萄糖转运蛋白-1(GLUT-1)和诱导型一氧化氮合成酶(iNOS)的表达水平及临床意义。方法检测70例胸腔积液患者(良性积液30例、恶性积液40例)血清和胸液中GLUT-1和iNOS的表达水平,并将检测结果进行对比。结果恶性组胸液中GLUT-1和iNOS水平显著高于良性组水平(P<0.01),血清中GLUT-1和iNOS水平略高于良性组,但无统计学意义(P>0.05),两组患者胸液中的GLUT-1和iNOS水平均高于同组血清中的水平。结论 GLUT-1和iNOS在恶性胸液中高表达,临床上检测二者的水平可能有助于恶性胸腔积液的诊断。
Objective To investigate the expressions and clinical significance of glucose transporter-1（GLUT-1） and inducible oxide synthase（iNOS） in malignant pleural effusions.Methods The levels of GLUT-1 and iNOS in serum and pleural effusion were determined in 70 patients with pleural effusions（30 cases of benign pleural effusion,40 cases of malignant pleural effusion） by enzymelinked immunosorbent assay.Results The levels of GLUT-1 and iNOS in pleural effusion were obviously higher in the malignant group than in the benign group（P〈0.01）,but they were slightly higher in the malignant group than in the benign group in serum（P〈0.05）.The serum levels of GLUT-1 and iNOS in pleural effusion were higher than those in serum in the same group.Conclusion GLUT-1 and iNOS show a high expression in patients with malignant pleural effusion,and it could be useful to detect the expression of GLUT-1 and iNOS in the diagnosis of malignant pleural effusion in clinic.
出处
《临床肺科杂志》
2013年第8期1487-1488,共2页
Journal of Clinical Pulmonary Medicine
