摘要
本文介绍了用人LDL培养的胎儿主动脉平滑肌细胞内SOD活性变化的趋势,结果显示,LDL在促进细胞增生的同时,能诱导细胞内SOD活性增高;而当细胞生长到一定程度后,SOD活性下降,出现细胞死亡;这些变化与动脉粥样硬化的病变相一致。
LDL and aorta media smooth muscle cells ( SMC ) are important factors in the processes of atherosclerosis genesis,the lipidperoxidation caused by free radical also regarded as a key factor in atherogenesis.Here introduced the variation of SOD activity within the SMC cultured with LDL-conditional medium. The results demonstrated that: LDL not only stimulated the growth of cells but also induced the activity of SOD decresed and the cell degeneration and death came about.
出处
《第一军医大学学报》
CSCD
1991年第4期302-304,共3页
Journal of First Military Medical University
关键词
LDL
AS
主动脉
SOD
平滑肌细胞
LDL
SOD
smooth muscle cell
lipidperoxidation
lipidperoxidate
free radical
atherosclerosis
