摘要
目的:探讨氨基末端脑钠肽前体(NT-ProBNP)对无创通气治疗慢性阻塞性肺病(COPD)伴肺心病疗效评估的价值及其意义。方法:将97例COPD急性加重期合并肺心病患者随机分为常规治疗组(47例)和无创通气组(常规药物治疗加上无创通气治疗)(50例),动态观察患者的血气分析指标及血浆NT-ProBNP浓度。结果:治疗后两组患者血气分析指标明显改善(P<0.05),两组患者治疗后NT-ProBNP水平均呈下降趋势(P<0.05),但无创通气组下降更明显(P<0.05)。结论:无创通气治疗COPD并肺心病患者的NT-ProBNP下降更显著,NT-ProBNP可用于无创通气治疗COPD并肺心病的疗效评估。
Objective：To investigate the value of N-terminal pro-brain natriuretic peptide（NT-ProBNP） in evaluating the clinical efficacy of noninvasive ventilation on patients with chronic obstructive pulmonary disease（C OPD） and cor pulmonale.Methods：Nighty-seven patients with acute exacerbation o f COPD patients with pulmonary heart disease,were randomly divided into two gro ups：routinal treatment group（47 cases）;noninvasive ventilation group（routina l treatment plus non-invasive ventilation）（50 cases）,and then detected blood gas analysis and the concentration of plasma NT-ProBNP.Results：After the treat ment,blood gas analysis index of patients′ in two groups improved significantl y（P0.05）,NT-ProBNP levels after treatment in the two groups were decrea sed（P0.05）,but the noninvasive ventilation group decreased more signific antly（P0.05）.Conclusion：NT-ProBNP were more significantly decreased aft er routinal treatment plus non-invasive ventilation,NT-Pro-BNP can be used t o evaluate the clinical efficacy of noninvasive ventilation in treatment of COPD and pulmonary heart disease.
出处
《临床医药实践》
2013年第7期488-491,共4页
Proceeding of Clinical Medicine
关键词
氨基末端脑钠肽前体
无创通气
慢性阻塞性肺病
肺心病
N-terminal pro-brain natriuretic peptide
non-inva sive ventilation
chronic obstructive pulmonary disease
cor pulmonale
