摘要
一氧化氮(nitric oxide,NO)是一种重要的多功能因子,能够介导许多生理功能,尤其是哺乳动物卵巢功能的调控。一氧化氮合酶(nitric oxide synthase,NOS)作为NO合成的限速酶,是调节NO合成的关键,具有神经型(neuronal NOS,nNOS)、诱导型(inducible NOS,iNOS)及内皮型(endothelial NOS,eNOS)三种类型。近年来的研究表明,NOS及一氧化氮/环鸟苷酸(nitric oxide/cyclic guanosine monophosphate,NO/cGMP)信号通路对哺乳动物的卵泡发育具有调节作用。该文就NOS及NO/cGMP信号通路在卵泡发育方面的主要研究进展进行评述并提出了展望。
Nitric oxide is a multifunctional factor mediating multiple biological effects, especially in regulation of mammalian ovarian functions. Nitric oxide synthases (NOS) are key rate-limiting enzymes in NO synthesis and have three types: neuronal NOS (nNOS), inducible NOS (iNOS) and endothelial NOS (eNOS). Recent studies showed that NOS and nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway had a great impact on mammalian follicular development. This article focuses on the effect and prospect of NOS and NO/cGMP signaling pathway on mammalian follicular development.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第7期1063-1067,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:31172206)资助的课题~~