摘要
目的探讨癫癎患儿血清神经元特异性烯醇化酶（NSE）水平与EEG变化的关系。方法选择230例确诊癫痫的患JL（癫癎组），分别于治疗前后（间隔1年）行长程视频EEG及血清NSE水平检查，同时检测74例健康儿童（健康对照组）血清NSE水平。结果癫癎组患儿治疗前血清NSE水平高于健康对照组（P〈0．001），全面性发作与局灶性发作2种发作类型之间NSE水平的差异无统计学意义（P=0．13）；治疗后血清NSE水平低于治疗前（P〈0．001），治疗后EEG异常程度显著好转，异常EEG组血清NSE高于正常范围EEG组及界限性EEG组，差异均有统计学意义（P均〈0．05），EEG异常程度与NSE水平呈正相关（L=0．605，P〈0．001）。结论癫癎患儿血清NSE变化与EEG异常一致，即EEG异常程度越重，NSE水平越高。血清NSE水平结合EEG检查可更好地评价癫痫患儿脑损伤程度。
Objective To investigate the relationship between the serum levels of neuron-specific enolase （NSE） and the severity of electroencephalogram（EEG） in children with epilepsy. Methods Two hundred and thirty epileptic children and 74 healthy children were enrolled in the study. Serum level of NSE was detected and video EEG was performed before and 1 year after treatment of the epileptic children respectively. Serum level of NSE in healthy control group was also detected. Results The serum level of NSE before treatment of the epileptic children was signifi- cantly higher than that of healthy control group（P 〈 0. 001 ）. There was no significant difference in serum level of NSE between generalized seizures and focal seizures （P = 0.13 ）. The serum level of NSE 1 year after treatment was signifi- cantly decreased compared with that before treatment （P 〈 0. 001 ） ,while the degree of severity on EEG was improved significantly. The serum level of NSE of abnormal EEG group was higher than that of the normal range EEG group and bounded EEG group（ all P 〈 0.05 ）, there was positive correlation between serum level of NSE and the severity of EEG （ r, = 0.605,P 〈 0. 001 ）. Conclusions The serum levels of NSE are related to the severity of EEG changes. Serum NSE combined with EEG can betterly predict the degree of brain damage in epileptic children.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2013年第12期917-919,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
国家自然科学基金（81071046）
广东省科技计划项目（20108031600159,20128032000009）
关键词
血清神经元特异性烯醇化酶
脑电图
癫癎
脑损伤
Serum neuron-specific enolase
Electroencephalogram
Epilepsy
Brain damage
