摘要
作者给小鼠S_(180)瘤体内直接注入研制的RS辐射增敏剂.结果:对照组瘤体不断增大,直至动物死亡,肿瘤平均10d增长率为77.1％(n=20).单独用辐射增散剂(RS)与单独放疗组结果接近,其10d增长率分别为47.5％(n=20)和47.1％(n=26).照射加RS组的10d增长率为-10.1％(n=26).本研究将增敏剂直接注入瘤体,可避免因瘤体循环差肿瘤区不易达到足够药物之弊.RS中除含有中药抑制癌的成分外,还含有一定量的H_2O_2.3％H_2O_2溶液每ml能释放10ml的氧,因而可使瘤体内有充分的氧以达到辐射增敏作用.
The present study performed in 92 tumor-bearing mice showed that a compound of traditional Chinese medicine with hydrogen peroxide which was injected directly into the tumors could in some extent sensitive the hypoxic cells of S180 solid tumor to radiate. For example, both the tumor regression rate within 40 days of radiation and hydrogen peroxide compound group were significantly greater than those of radiation alone group. The increasing rate of tumor diameter in 10 days was 77.1%, 47.0% and -10.1% in group control, radiation alone and radiosensitizer alone, radiation and hydrogen peroxide compound respectively. Some of the problems about the intratumoral injection of radiosensitizer were discussed.
出处
《第四军医大学学报》
1991年第1期30-32,共3页
Journal of the Fourth Military Medical University
关键词
放射疗法
辐射增敏剂
瘤体
radiotherapy
odl hypoxia
radiosensitizer, intratumoral injection
