摘要
目的探讨胃癌相关抗原(MG7)与癌胚抗原(CEA)在胃癌、胃癌早期病变及胃黏膜疾病中的变化和意义。方法选取该院消化内科共178个病例。其中,胃癌和胃癌前病变(包括萎缩性胃炎、病理报告提示胃黏膜肠上皮化生和不典型增生的患者)88例作为检测组,胃黏膜疾病(包括慢性浅表性胃炎、胃溃疡、十二指肠球部溃疡和胃息肉)患者90例作为对照组,空腹抽血,分离血清放入-700℃冰箱保存备检。结果检测组胃癌48例的胃癌相关抗原(MG7)有45例均为阳性,胃癌前病变组40例,22例阳性,胃黏膜疾病组90例,18例为阳性,两组的MG7及CEA检测结果,经χ2检验,差异存在显著性(P<0.01)。结论胃癌相关抗原与癌胚抗原联合检测,对胃癌及胃癌早期病变中能进行早期诊断,可在临床推广使用。
[ Objective ] To discuss change and significance of MG7 and CEA in gastric cancer and gastric cancer early lesions and gastric mucosal diseases. [ Methods ] 178 patients in the G1 medicine in my hospital were recruit- ed . 88 cases of testing group including atrophic gastritis and pathology report suggested gastric mucosa intestinal metaplasia and atypical hyperplasia patients） and control group 90 case including chronic superficial gastritis and gastric ulcer and duoclenal bulb ulcer and gastric polyps）, fasting blood and separation of serum and preservation at -700~C in the refrigerator be detected. [Result] The experimental group of 45 cases MG7 were positive in the 48 cases gastric cancer and the gastric cancer early lesions 22 cases MG7 were positive in the 40 cases and gastric mu- cosal diseases 18 cases were positive in the 90 cases. There were statistically significant difference of MG7 and CEA between the two groups （P 〈0.01）. [Conclusion] The MG7 and CEA testing can make early diagnosis to gastric cancer and gastric mucosal diseases and can be widely used in clinical practice.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第10期98-100,共3页
China Journal of Modern Medicine
