摘要
目的探讨姜黄素(curcumin)对Aβ1-42诱导的老年痴呆(Alzheimer’s disease,AD)大鼠认知功能的影响及意义。方法将SD大鼠随机分为AD大鼠模型,假手术组及姜黄素组,将Aβ1-42微量注射至大鼠右侧海马,制作AD大鼠模型,一个月后进行定位航行和空间探索水迷宫试验,分别检测大鼠的学习和记忆能力;姜黄素干预组于AD建模后24 h给予300 mg/(kg.d)二甲基亚砜(DMSO)溶解的姜黄素,连续腹腔注射5d;一个月后进行定位航行和空间探索水迷宫试验分别检测各组的学习和记忆能力。结果与假手术组相比,AD模型组大鼠显示学习、记忆能力显著下降(P=0.013);与AD模型组分别对比,姜黄素干预后大鼠空间学习记忆能力明显改善(P=0.021)。结论姜黄素有改善Aβ1-42诱导的AD模型大鼠空间学习记忆障碍的作用。
[ Objective ] To investigate the effect and significance of eureumin on cognitive impairment of AD model rats after Aβ1-42
injected into hippocampus. [Methods] The SD rats were divided into three groups： sham group, AD model group and curcumin administrated group. Aβ1-42 was micro-injected into the right hippocampus of rats. 24 h after the injection, Curcumin dissolved with DMSO [300 mg/（kg＇d）] was administrated by intraperitoneal injection to the AD model group for 5 d. One month later, Morris water maze （MWM） was used to study the learning and memory ability in each group every day. [Result] MWM test showed that the rats in AD model group had longer escape latencies compared with those in control group （P =0.013）, and the rats in cureumin group had shorter escape latencies compared with those in model group （P =0.021）. [ Conclusion ] Curcumin can partly improve the spatial learning and memory dysfunction of AD model rats.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2013年第10期16-19,共4页
China Journal of Modern Medicine
基金
辽宁科技计划项目(No:2011020216-406)
沈阳市科技项目(No:F10-149-9-56)
