摘要
[目的]探究姑息性手术联合区域性动脉灌注化疗对晚期胰头癌的疗效。[方法]将我院2006年1月至2011年12月间收治的不可根治性切除的晚期胰头癌36例患者随机分为实验组和对照组。实验组联合姑息性手术与动脉灌注化疗进行治疗,对照组采用常规药物对症治疗,两组患者均进行营养支持以及护理支持等疗法。术后就生存率、生活质量等情况进行随访。[结果]实验组6个月、12个月生存率分别为77.8%、38.9%,优于对照组的38.9%、5.6%,差异均有统计学意义(P<0.05),实验组的整体生存时间较对照组明显延长;实验组患者在心理、躯体、精神、社会4方面质量指标评分均明显优于对照组,差异有统计学意义(P<0.05)。[结论]对无法行根治性切除术的晚期胰头癌患者,采用姑息性手术联合动脉灌注化疗可提高患者生活质量,增加患者生存时间,改善患者预后。
[Objective]To investigate the clinical efficacy of palliative operations combined with regional intra arterial chemotherapy for the treatment of advanced pancreatic head adenocarcinoma.[Methods]36 patients with advanced pancreatic head adenocarcinoma which could not be radically resected were randomly divided into experimental and control groups.The patients in experimental group received palliative operations combined with regional intra arterial chemotherapy,while the patients in contol group just received conventional drug therapy.All patients in both groups received conventional clinical therapy such as nutritional support and nursing support.[Results]The 6-month survival rate in experimental group was 77.8%,which was significantly higher than the one in control group（38.9%,P=0.0425）.The 12-month survival rate in experimental group was 38.9%,which was also significantly higher than the one in control group（5.6%,P=0.0450）.Overall survival time in experimental group was significantly longer than the one in control group.Living quality indexes such as body,psychology,society and spirit in experimental group were significantly superior to the control group.[Conclusion]For the patients with advanced pancreatic head adenocarcinoma which can not be radically resected,palliative operations combined with regional intra arterial chemotherapy can improve quality of life,prolong survival time and improve the prognosis of patients.
出处
《浙江中医药大学学报》
CAS
2013年第5期554-556,共3页
Journal of Zhejiang Chinese Medical University
关键词
胰头癌
晚期
不可切除
姑息性手术
动脉灌注化疗
pancreatic carcinoma
advanced stage
can’t be resected
palliative operation
arterial chemotherapy
