摘要
作者采用免疫组化方法对大肠癌,移行粘膜,大肠息肉及胎儿大肠进行MC_3标记观察,阳性率分别为:大肠癌95.38％,移行粘膜47.00％,胎儿大肠70.83％,家族性息肉65.08％,绒毛状腺癌69.23％,管状腺瘤42,00％,幼年性息肉37.50％。另外,阳性率随息肉增生级别增高而递增。结果提示,MC_3可作为大肠息肉癌变倾向的检测指标。移行粘膜存在有癌前病变。
The monoclonal antibody MC_3 related antigen was expressed in colon carcinoma, its transitional mucosa, colon polyp and fetal colon mucosa with immunohistochemical staining.The positive rate was 95.38%,47.00%,70.83%, 65.08%, 69.23%, 42.00%, and 37.50% in colon carcinoma, transitional mucosa, fetal colon mucosa, familial polyp, villus adenoma, tubular adenoma and infantile polyp respectively. Moreover, the positive rate became higher as the proli-ferative grading of polyps was larger.The findings suggest that monoclonal antibody MC_3 can be used as a means to detect the possible cancerous degeneration of colon polyps and transitional mucosa of the colon can be considered as a precancerous lesion.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1991年第3期239-242,共4页
Journal of Third Military Medical University
关键词
大肠肿瘤
单克隆抗体
肠息肉
病理
antibodies, monoclonal
intestinal neoplasms
inrestinal polyps
intestinal mucosa/PA
