摘要
目的比较两种根治幽门螺杆菌(Hp)相关性胃溃疡方案的临床疗效,为治疗方案的选择提供参考。方法选取2010年9月-2012年8月于医院进行治疗的84例Hp相关性胃溃疡患者为研究对象,将其随机分为A组(奥美拉唑、阿莫西林及克拉霉素组)和B组(埃索美拉唑、阿莫西林及克拉霉素组),各42例;然后将两组患者的治疗总有效率、Hp根除率及总的不良反应发生率进行比较。结果 B组的治疗总有效率为100.00%,明显高于A组,Hp根除率为97.62%,也高于A组,而总的不良反应发生率为2.38%,低于A组,差异均有统计学意义(P<0.05)。结论埃索美拉唑、阿莫西林及克拉霉素在Hp相关性胃溃疡中的疗效与安全性均相对较高。
OBJECTIVE To compare the clinical efficacy of two programs in eradication of Helicobacter pylori（Hp）-related gastric ulcer so as to guide the clinical treatment.METHODS A total of 84patients with Hp-related gastric ulcer,who were treated in the hospital from Sep 2010to Aug 2012,were enrolled in the study and were randomly divided into the group A（omeprazole,amoxicillin and clarithromycin ADR group）and the group B（esomeprazole,amoxicillin and clarithromycin group）with 42cases in each,then the total effective rate of treatment,the eradication rate of Hp,and the incidence of adverse reactions were compared between the two groups.RESULTS The total effective rate of treatment of the group B was 100.00%,significantly higher than that of the group A;the eradication rate of Hp of the group B was 97.62%,significantly higher than that of the group A;however,the incidence of the adverse reactions of the group B was 2.38%,lower than that of the group A,the difference was statistically significant（P〈0.05）.CONCLUSION The efficacy and safety of esomeprazole,amoxicillin and clarithromycin are relatively high in the treatment of Hp-associated gastric ulcers.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第13期3133-3134,共2页
Chinese Journal of Nosocomiology
基金
潍坊市科学技术局项目(20090826AS)
关键词
治疗方案
幽门螺杆菌相关性胃溃疡
疗效
安全性
Treatment program
Helicobacter pylori-associated gastric ulcer
Efficacy
Safety
