摘要
作者报道了肿瘤光化学诊治剂癌光啉(PsD-007)的化学组成,所含各成分的分离、结构鉴定和主要成分的肿瘤光生物活性。HPLC分析结合波谱测定结果表明,PsD-007由MHD、DMD、MVD、AHD、HVD、Hp和Pp等7种不同卟啉组成。肿瘤光生物活性测定结果提示,MHD、MVD、DMD为PsD-007的肿瘤光生物活性成分。
The chemical composition, separation and identification of the components as well as the tumor photobiological activities of the major components of the new tumor-photochemodiagnostic and photochemotherapeutic agent photocarcinorin (PsD-007) were represented in this paper. It has been shown by the results of HPLC analysis in combination with spectroscopic determinations that PsD-007 is composed of 7 different porphyrins: MHD, DMD, MVD, AHD, HVD, Hp and Pp. The experimental results show that MHD, DMD and MVD are the major tumor photobiologically active components of PsD-007.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第3期208-214,共7页
Academic Journal of Second Military Medical University
关键词
癌光啉
抗癌药
光生物活性
photocarcinorin
photodynamic therapy
photochemodiagnosis and photochemotherapy
photosensitizing ability
photoinactivation
photobiological activity
