摘要
采用荧光偏振法,测得帕金森病患者红细胞膜微粘度(0.3637±0.0041Pa·S)显著高于正常人(0.2299±0.0158Pa·s);同时红细胞胰岛素结合实验表明,患者红细胞胰岛素受体位点(90.08±23.18Sites/RBC)显著低于正常人(215.30±116.20Sites/RBC)。两指标间呈有意义的负相关(r=-0.6811,P<0.05)。用6-OHDA损毁家兔一侧黑质后,外周血中红细胞膜微粘度也明显升高,与患者红细胞膜脂区流动性变化结果一致。
The membrane microviscosity and insulin receptor of erythrocytes were determined by fluorescence polarization analysis and insulin radioligand binding assay simultaneously. The patients with Parkinson disease (PD) had increased membrane microviscosity (P<0.01) and decreased insulin receptor sites (P<0.01) as compared with the control group. A significant negative correlation was found between the two parameters (r=-0.6811,P<0.05), suggesting that decreased membrane fluidity might be one of the factors leading to the decrease of insulin receptor sites. The membrane microviscosity of erythrocytes in the rabbits with parkinsonism induced by injecting 6-hydroxydopamine into unilateral substantia nigra was increased significantly (P<0.05). Our results indicate that the functions of erythrocytes seem to be affected by the lesion of substantia nigra.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第3期218-220,共3页
Academic Journal of Second Military Medical University
关键词
震颤性麻痹
胰岛素
受体
膜脂区
Parkinson disease
membrane microviscosity
membrane fluidity
insulin receptor
