摘要
本文报道基因工程人αB干扰素(Recombinant human interferon-αB,rHuIFN-αB)对小鼠的急性毒性和夫鼠的长期毒性。rHuIFN-αB肌注小鼠急性毒性LD_(50)>10~9IU/m^2,大鼠长期毒性所有观察指标(一般行为活动、食量、粪便、体重、体温,血象、牛化指标和病榆器官等)在给药组和对照组间未见明显差别,表明大鼠肌注rHuIFN-αB相当于推荐临床剂量的30倍,连续3个月,未显示药物性毒性反应。
The present article reports the acute toxicity of recombmant human interferon-αB (rHuIFN-αB) in mice and its long-term toxicity in rats. The results showed that rHuIFN-αB im LD50>10 9 TU/m2 and there were no significant differences of all parameters (appearance, vitality, activity, appetite, urine, stool, body weight, temperature, blood chemistry, biochemistry and pathological findings) between the medicinal group and normal control group. So there were no toxic reactions in rats when rHuIFN-αB was given 30 times as much as the recommended clinical dosage for three months.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第2期114-118,共5页
Academic Journal of Second Military Medical University
关键词
基因工程
干扰素类I型
毒性
genetic engineering
interferon type Ⅰ
toxicity
mice
rats
