摘要
用M-8601型膜天平比较内毒素血症大鼠与正常大鼠血浆对支气管-肺泡灌洗液(BAL)表面特性的影响。发现内毒素血症大鼠血浆对BAL表面活性有明显抑制作用,其抑制强度与相同蛋白浓度的正常大鼠血浆基本相同。两种血浆分别与BAL在37℃下孵育30min后抑制作用无显著差异。提示内毒素性肺损伤时血浆渗出对肺泡表面活性物质的抑制主要与血浆蛋白有关。
The inhibition of bronchoalveolar surfactant function by endotoxic rat plasma was compared with that by normal rat plasma with M-8601 film balance. The results showed that endotoxic rat plasma significantly inhibited surfactant function of bronchoalveolar lavage (BAL). In the same protein concentration, the inhibition effects caused by endotoxic rat plasma were comparable with those by normal rat plasma. There were no changes of the inhibition effects after incubation of BAL with either endotoxic or normal plasma at 37℃ for 30min. These results suggest that the inhibition of surfactant function by the leakage of plasma in endotoxic lung injury is mainly due to protein components.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1991年第2期106-109,共4页
Academic Journal of Second Military Medical University
关键词
肺泡
表面活性物质
内毒素
膜天平
pulmonary surfactant
endotoxin
film balance
plasma proteins
rats
