摘要
目的探讨丹红注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效及作用机制。方法将85例AECOPD患者随机分为治疗组43例及对照组42例,均给予常规西医疗法,治疗组在此基础上加用丹红注射液静脉滴注。比较两组患者治疗前后中医证候积分、动脉血气分析、血液流变学指标、改良圣乔治呼吸问卷(SGRQ)各领域积分的变化以及不良反应。结果治疗组中医证候积分、氧分压(PaO2)、二氧化碳分压(PaCO2)、全血黏度、血浆黏度、红细胞压积以及日常生活和焦虑心理两个领域的积分改善幅度显著大于对照组,且两组均未观察到明显不良反应。结论在常规西医治疗基础上加用丹红注射液静脉滴注可有效改善AECOPD患者的血液循环,从而缓解临床症状,改善通气功能,对日常生活能力的提高和心理状态的优化具有积极作用,安全性好,值得临床推广。
Objective To explore the clinical effect and mechanism of Danhong Injection on acute exacerbations of chronic obstructive pulmonary disease （AECOPD）. Methods Eighty-five cases of patients with AECOPD were divided into treatment group （n=43） and control group （n = 42）. The two groups both received conventional western medicine therapy, while the treatment group were added Danhong Injection. The changes of TCM syndrome scoring, arterial blood gas analysis, hemorheology indicators, modified Saint George＇s respiratory questionnaire （SGRQ） before and after treatment and adverse reactions in two groups were compared. Results The improving degrees of TCM syndrome scoring, oxygen partial pressure （PaO2）, carbon dioxide partial pressure （PaCO2）, whole blood viscosity, plasma viscosity, hematokrit and scoring in the field of daily life and anxiety in treatment group were significantly greater than that in control group. There was no obvious adverse reaction in two groups. Conclusion On the basis of conventional western medicine therapy,combined with Danhong Injection can effectively improve blood circulation in patients with AECOPD, and thus relieve the clinical symptoms, improve ventilation function. Besides, it has a positive effect on the improvement of ability of daily life and mental state and high security. It＇s worthy of clinical promotion.
出处
《成都医学院学报》
CAS
2013年第3期313-315,共3页
Journal of Chengdu Medical College
基金
中国高校医学期刊临床专项资金项目(NO:11320079)
关键词
阻塞性肺疾病急性加重期
丹红注射液
中西医结合
血液流变学
Acute exacerbations of chronic obstructive pulmonary disease
Danhong injection
Integrated traditional Chinese and western medicine
Hemorheology
