摘要
目的探讨水杨酸钠(SS)是否对顺铂(CDDP)所致的豚鼠耳毒性具有保护作用。方法将48只豚鼠随机分为4组:A组(对照组)、B组(SS组)、C组(CDDP组)、D组(SS+CDDP组),每组12只。对每组豚鼠右耳测用药前、后听性脑干反应(ABR)阈值;每组随机取6只耳蜗,通过免疫组化测定各组耳蜗螺旋神经节细胞(SGC)中Caspase-3的表达情况。结果 A组与B组用药后ABR阈值、SGC的Caspase-3表达量比较差异均无显著统计学意义(P>0.05);C、D组用药后ABR阈值、SGC的Caspase-3表达量明显高于A、B组(P<0.05);D组用药后ABR阈值、SGC的Caspase-3表达量明显低于C组(P<0.05)。结论水杨酸钠对顺铂所致的耳毒性具有一定的保护作用。
Objective To explore the protective effect of sodium salicylate （SS） on the ototoxicity of cisplatin（CD-DP） in guinea pigs. Methods 48 guinea pigs were randomly divided into four groups： group A （control group） ,group B （SS group） ,group C （CDDP group） and roup D （SS＋CDDP group） ,each of 12 animal. Measured the auditory brainstem response （ABR） threshold of each animal before and after treatment. 6 cochleae were randomly selected in each group. The Caspase 3 expression of cochlear spiral ganglion cells was determined through immunohistochemistry. Results The ABR threshold and Caspase-3 expression of SGC had no significant in group A compared with group B （P0. 05） . The ABR threshold and Caspase-3 expression of SGC in group C,D was significantly higher than that of group A,B （P0. 05） . The ABR threshold and SGC Caspase-3 expression of group D was significantly lower than that of group C （P0. 05） . Conclusion Sodium salicylate can reduce the ototoxicity of cisplatin.
出处
《临床合理用药杂志》
2013年第17期10-11,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
水杨酸钠
顺铂
耳毒性
保护作用
Sodium salicylate
Cisplatin
Ototoxicity
Protective effecte
