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应用Identifiler^(TM)系统对湖南人群中OL等位基因的观察与分析 被引量：4

Analysis of OL Allele of Identifiler^(TM) System in Hunan Population
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摘要 应用IdentifilerTM系统和ABI310型遗传分析仪,对湖南人群中3 423例无关个体进行基因分型,筛选出OL等位基因,并对其分布及构成进行分析.结果显示在3 423例个体基因分型中,发现12种OL等位基因,分布于D13S317、D19S433、D21S11、D3S1358、D7S820和FGA等6个基因座,各基因座OL等位基因的种类数目为1～3个,位点频率为0.292‰～9.641‰.通过以上研究,可对IdentifilerTM系统群体遗传多态性数据进行有效的补充和完善,从而使其更好地应用于人类生物学、法医遗传学等领域. Samples from 3 423 unrelated individuals in Hunan population have been tested by using Identi- filerTM system kit and ABI 310 genetic analyzer. Off-ladder （OL） alleles were screened, and their size distri- bution and composition were analyzed. The results indicated that 12 OL alleles were found in D13S317, D19S433, D21Sll, D3S1358, D7S820 and FGA, whose frequencies ranged from 0.292‰-9.641‰. The number of OL alleles varied from 1 to 3 at 6 loci. Therefore, the genetic polymorphism data of IdentifilerTM system can be supplemented to OL allele studies, and it provides significant insights into application and re- search in the field in human biology and forensic genetics.
作者 欧阳曙明 杨旭 申琴 刘腾 倪斌
机构地区 湖南省计划生育研究所现代优生技术湖南省重点实验室 南华大学附属第一医院妇产科
出处 《生命科学研究》 CAS CSCD 北大核心 2013年第3期193-195,共3页 Life Science Research
基金 湖南省科技厅资助项目(2012SK3276)
关键词 IdentifilerTM系统 OL等位基因 STR基因座 IdentifilerTM system off-ladder allele short tandem repeat locus
分类号 Q347 [生物学—遗传学]
  • 相关文献

参考文献11

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二级参考文献21

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共引文献25

同被引文献28

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二级引证文献13

生命科学研究
2013年 第3期

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