摘要
目的伊贝沙坦与复方丹参联合应用对早期糖尿病肾病患者肾功能及血液流变学的影响及安全性。方法 80例早期糖尿病肾病患者采用随机数字表法分为观察组和对照组各40例,均给予糖尿病常规治疗,在此基础上,对照组加用贝那普利,观察组加用伊贝沙坦及复方丹参,治疗3个月后评价对肾功能及血液流变学的影响。结果①两组治疗后空腹血糖(FPG)、餐后2 h血糖(P2 hPG)、糖化血红蛋白(HbA1c)水平均无明显变化,治疗前后差异均无统计学意义(P>0.05)。②两组血尿素氮(BUN)、24 h尿蛋白量、收缩压、舒张压较治疗前均明显下降(P<0.05),肌酐清除率(Ccr)明显上升(P<0.05),但观察组BUN、24 h尿蛋白量和Ccr改善更明显(P<0.05)。③治疗后观察组血液流变学各项指标明显改善(P<0.05),而对照组与治疗前比较变化不大(P>0.05)。④两组均未发生严重不良反应。结论伊贝沙坦与复方丹参联合应用治疗早期糖尿病肾病患者,可以有效降低血压,改善肾功能及血液流变学,安全性高,值得临床推广应用。
Objective To investigate the effects of irbesartan combined with dan-shen root on the kidney function and the hemorheology in patients with early diabetic nephropathy. Methods Eighty patients with early diabetic nephropathy were randomly divid- ed into observation group and control group ,40 patients each group. All the patients were treated with conventional therapy for diabe- tes. The control group was additionally treated with benazepril while the observation group additionally treated with irbesartan and dan- shen root. The effects were evaluated in 3 months after treatment. Results：①No significant changes in fasting plasma glucose（ FPG）, postprandial 2 h plasma glucose（ P2 hPG）and glyeosylated hemoglobin（HbAle） were found neither in the control or the observe group before and after the treatment. ②In the two groups, blood urea nitrogen （BUN） ,24 h urine protein volume, systolic pressure and dias- tolic pressure were significantly decreased while creatinine clearance rate（Ccr） was significantly increased after 3 months of the treatment when compared to treatment before（ all P 〈 0.05 ）. However,the improvement of 24 h urine protein volume and Ccr in the obser- vation group were more significantly than that in the control group（ P 〈 0.05 ）. ③The hemorheological indexes of the observation group were significantly improved（ P 〈 0. 05 ）while no significant changes was found in the control group after 3 months of the treatment when compared to treatment before. （~No severe adverse reaction occurred neither in the control or the observe group. Conclusions The treatment with irbesartan combined with dan-shen root for early diabetic nephropathy can effectively decrease blood pressure, improve kidney function and hemorheology, and is highly safe. Therefore, the treatment is worthy of clinical application.
出处
《实用医院临床杂志》
2013年第4期152-154,共3页
Practical Journal of Clinical Medicine
