摘要
目的研究彝族人群类风湿性关节炎(rheumatoid arthritis,RA)患者伴发甲状腺功能异常的情况及临床意义。方法以确诊为RA的彝族人群患者42例为观察组,同期彝族人群健康体检者42例为对照组。采用化学发光分析法检测两组受试者甲状腺功能、促甲状腺激素和抗甲状腺自身抗体,常规检测实验室检查项目、免疫学指标等,并进行对比。对甲状腺功能正常与异常RA患者的疾病活动度、血沉、免疫球蛋白、补体、肝肾功能及血常规等进行比较。结果观察组甲状腺功能异常率(54.76%)、类风湿因子(rheumatoid factor,RF)阳性率(73.81%)、免疫球蛋白水平、甲状腺激素水平、抗甲状腺自身抗体值显著高于对照组(P<0.05);甲状腺功能正常与异常RA患者间RF阳性率、疾病活动度(DAS28)、血沉(ESR)、免疫球蛋白、补体、肝肾功能及血常规差异均无统计学意义(P>0.05)。结论彝族人群RA患者易出现甲状腺功能异常。
Objective To investigate the abnormalities of the thyroid functions in Yi Chinese patients with rheumatoid arthritis （RA） and implications for clinical practice. Methods Among 42 Yi Chinese patients with established RA and 42 healthy controls, the thyroid functions, thyroid stimulating hormones and anti-thyroid autoantibodies as well as routine laboratory tests and immunological markers were detected. We compared the disease activities, erythrocyte sedimentation rates, immunoglobulins, complements, liver and re- nal functions and complete blood counts between the normal and abnormal thyroid function groups. Results In RA group, the preva- lence of abnormal thyroid functions （54. 76% ）, the positive RFs （73.81% ）, the levels of immunoglobulin, thyroid hormone and anti- thyroid autoantibodies were significantly higher than that of the control group. However, there were no significant differences in the posi- tive rate of RA, disease activity （DAS28）, erythrocyte sedimentation rate, immunoglobulins, complements,liver and renal functions and complete blood counts between normal and abnormal thyroid function groups. Conclusions Yi Chinese patients with RA are prone to have abnormal thyroid functions.
出处
《实用医院临床杂志》
2013年第4期110-112,共3页
Practical Journal of Clinical Medicine
