摘要
目的根据不同性别及不同年龄组建立山西地区的丙氨酸氨基转移酶(ALT)正常值上限(ULN),重新评估血清ALT ULN。方法以连续监测法检测2012年1月至2012年6月山西地区体检的2312例成人血清ALT水平,符合纳入标准的健康成人共1457例。根据单样本Kolmogorov-Smirnov检验ALT值呈正态分布,比较不同性别之间、相同性别不同年龄组及不同性别相同年龄组之间血清ALT水平的差异。结果不同性别之间血清ALT水平差异具有统计学意义(t=8.9,P<0.05),且男性血清ALT水平高于女性,男性ALT ULN为49.8U/L,女性为33.8U/L。男性随着年龄的增加,血清ALT水平呈下降趋势,20～29岁组与50～59岁组、60～69岁组、≥70岁组差异均具有统计学意义(F=35.6,P<0.05),≥70岁组与20～29岁组、30～39岁组、40～49岁组差异均具有统计学意义(P均<0.05),其他各组差异无统计学意义(P>0.05)。其中,男性中20～29岁组ALTULN最高(57.5U/L),≥70岁组最低(35.5U/L)。女性随着年龄的增加血清ALT水平呈波浪形趋势,≥70岁组与20～29岁组、30～39岁组差异具有统计学意义(P<0.05),其他各组间差异无统计学意义(P>0.05)。女性中40～49岁组血清ALTULN最高(44.9U/L),30～39岁组最低(30.3U/L)。健康人群中不同性别、相同年龄组血清ALT水平存在差异,其中60～69岁组与≥70岁组差异无统计学意义(P均>0.05),其他各组间差异均具有统计学意义(P均<0.05)。结论需根据不同地区、不同性别及不同年龄组建立不同的ALT ULN。
Objective To reevaluate the serum alanine aminotransferase （ALT） upper limit of normal （ULN） in Shanxi area based on different gender and age cases. Methods The serum ALT levels in 2312 adult taking physical examination from January 2012 to June 2012 in Shanxi area were detected by continuous monitoring method. Total of 1457 healthy adults meeting the inclusion criteria were selected. The single sample Kolmogorov-Smirnov test showed that the detected ALT values was on normal distribution. The levels of ALT in different sex groups, same sex but different age groups and different ages but the same sex group were compared. Results The levels of ALT in serum between different sex cases were with significant differences （t = 8.9, P 〈 0.05）, the results showed that the ALT values in men cases were significantly higher than that of women, ALT ULN in men was 49.8 U/L while 33.8 U/L in women. With age increasing, the serum ALT levels decreased in men patients. Compared with 50-59 years old group, 60- 69 years old group and ≥ 70 years old group, the ALT level of patients in 20-29 years old were significantly different （F = 35.6, P 〈 0.05）. Compared with 20-29 years old group, 30-39 years old group, 40-49 years old group, the ALT level of patient in ≥ 70 years old group were significantly different （P 〈 0.05）, but the other groups were with no significant difference （P 〉 0.05） among the other groups. The ALT ULN in men cases of 20-29 years group was with the maximum as 57.5 U/L and in ≥ 70 years group was the lowest as 35.5 U/L. With the age increasing, the serum ALT levels showed wavy trend in women patients. Compared with 20-29 years old group and 30-39 years old group, the ALT levels of women patients in≥ 70 years old group were significantly different （P 〈 0.05）, but with no significant difference （P 〉 0.05） among the other groups. The ALT ULN in 40-49 years old group was with the maximum as 44.88 U/L and 30-39 years old group was with the lowest as 30.3 U/L in women cases. The serum ALT levels of healthy people in the same age but difference gender groups had significant difference. Compared the 60-69 years old groups and ≥ 70 age group, there was no significant different among the serum ALT levels （P 〉 0.05）, but the differences were significant in other groups （P 〈 0.05）. Conelusion A new ALT ULN should be determined based on different regions, different genders and different ages.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2013年第2期54-57,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
关键词
丙氨酸氨基转移酶
正常值上限
Alanine aminotransferase （ALT）
Upper limit of normal （ULN）
