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苏木乙酸乙酯提取物对荷瘤鼠CD4^+CD25^+foxp^(3+)表达的干预作用 被引量：4

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摘要 目的:观察苏木乙酸乙酯提取物对荷瘤小鼠CD4+CD25+foxp3的作用机制。方法:采用lewis肺癌荷瘤小鼠模型,将接种后的小鼠分为对照组、苏木低剂量组、苏木木高剂量组,采用流式细胞仪等方法检测各组小鼠脾细胞CD4+CD25+foxp3的表达情况。结果:苏木各剂量组均能使CD4+CD25+foxp3+的表达降低,且与剂量呈负相关。结论:苏木乙酸乙酯提取物能够调节CD4+CD25+foxp3+调节性T细胞,这可能是其抑制小鼠Lewis肺癌生长转移,延长生存的作用靶点之一。
作者 客蕊 周亚滨 赵志成 张春芳 石岚
机构地区 黑龙江中医药大学附属第一医院
出处 《中医药学报》 CAS 2013年第3期83-84,共2页 Acta Chinese Medicine and Pharmacology
基金 黑龙江省教育厅科学技术面上项目(No.12531613) 黑龙江中医药大学创新人才项目
关键词 苏木乙酸乙酯 荷瘤小鼠 CD4+CD25+foxp3+ 调节性细胞
分类号 R285.5 [医药卫生—中药学]
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共引文献24

同被引文献60

  • 1于波,侯静波,吕航.苏木提取物对心脏移植大鼠T淋巴细胞亚群的免疫抑制和对心肌的保护作用[J].中国地方病学杂志,2004,23(6):539-542. 被引量：12
  • 2崔丽丽,于波.苏木水提取物的抗急性排斥与Th1/Th2免疫偏移作用[J].中国胸心血管外科临床杂志,2006,13(4):255-259. 被引量：9
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中医药学报
2013年 第3期

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