糖化血红蛋白和尿微量白蛋白对2型糖尿病肾损伤早期的诊断价值被引量：3

导出

摘要目的研究糖化血红蛋白(HbA1c)与尿微量白蛋白(mAlb)联合测定与2型糖尿病肾脏早期损伤的关系。方法选择108例2型糖尿病患者(分为常规尿蛋白阳性组和常规尿蛋白阴性组)及同期健康体检者60例进行研究,分别检测HbA1c、尿mAlb、尿素氮BUN、肌酐Cr和尿酸UA,并应用统计学方法进行分析。结果糖尿病患者各组的HbA1c、mAlb水平明显高于正常对照组(P<0.01);糖尿病尿蛋白阳性组的BUN、Cr、UA水平高于糖尿病尿蛋白阴性组(P<0.01);糖尿病尿蛋白阴性组BUN、Cr、UA水平与对照组比较差异无统计学意义(P>0.05)。结论糖化血红蛋白和尿微量白蛋白比尿素氮、肌酐和尿酸能更早发现和诊断糖尿病肾损伤。

作者沈爱蓉闫国庆周艳茹

机构地区北京市顺义区空港医院检验科

出处《中国实用医药》 2013年第16期125-126,共2页 China Practical Medicine

关键词 2型糖尿病糖化血红蛋白尿微量白蛋白肾功能损伤联合检测

分类号 R587.2 [医药卫生—内分泌]

引文网络
相关文献

参考文献7

1Frohlich-Reiterer EE, Borkenstein MH. Microvascular and macro- vascular complications in children and adolescents with type 1 dia- betes mellitus. Diabetes Technol Ther, 2010, 160 ( 15-16 ) : 414-418.
2Syed IA, Khan WA. Glycated haemoglobin-a marker and predictor of cardiovascular disease. J Pak Med Assoc, 2011, 61 ( 7 ) : 690-695.
3Tagle R, Gonz6lez F, Acevedo M. cal practice. Rev Med Chil, 2012, urinaryal- 140(6) : 797 -805.
4McCrary EB. The road to renal failure : an overview of diabetic ne- phropathy. Adv Nurse Pract, 2008,16(7) :61-63.
5Reutens AT, Atkins RC. Epidemiology of diabetic nephropathy. Contrib Nephro1,2011, 170 : 1-7.
6巫素婷,彭林平.初诊2型糖尿病患者糖化血红蛋白与并发症的关系[J].检验医学与临床,2012,9(9):1062-1063. 被引量：5
7程苏琴,朱美财.尿微量白蛋白在糖尿病肾损伤早期诊断中的价值[J].中华检验医学杂志,2005,28(7):740-741. 被引量：201

二级参考文献11

1林兰,魏军平.小心糖尿病引发尿毒症[J].糖尿病新世界,2003,0(4):12-13. 被引量：4
2Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010,362 (12):1090-1101.
3Ross SA,Dzida G,Vora J, et al. Impact of weight gain on outcomes in type 2 diabetes [J]. Curr Med Res Opin, 2011,27(7) :1431-1438.
4Nathan DM,Chew S, Fowler S, et al. The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the Diabetes Prevention Program[J]. Diabet Med, 2007,24(2): 137-144.
5Motta M,Bennati E,Cardillo EL,et al. The value of glycosylated hemoglobin(HbAlc) as a predictive risk factor in the diagnosis of diabetes mellitus(DM) in the elderly [J]. Arch Gerontol Geriatr, 2010,50 (1) : 60-64.
6Selvin E,Steffes MW,Zhu H,et al. Glycated hemoglobin, diabetes,and cardiovascular risk in nondiabetic adults[J]. N Engl J Med,2010,362(9) :800-811.
7Syed IA. Glycated haemoglobin; past, present, and future are we ready for the change[J]. J Pak Med Assoc,2011, 61(4):383-388.
8Deedwania P, Srikanth S. Diabetes and vascular disease[J]. Expert Rev Cardiovasc Ther, 2008,6 (1):127-138.
9Redon J, Cifkova R, Laurent S, et al. Mechanisms of hypertension in the cardiometabolic syndrome[J]. J Hypertens,2009,27(3) :441-451.
10Thomas GN, Tomlinson B. Prevention of macrovascular disease in type 2 diabetic patients: blockade of the renin angiotensin-aldosterone system [J]. Curr Diabetes Rev, 2008,4(1):63-78.