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甲状腺微小乳头状癌107例术中冷冻切片诊断分析 被引量：2

An Analysis on Diagnosis of Intraoperative Frozen Section in 107 Cases with Thyroid Papillary Microcarcinoma
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摘要 [目的]探讨甲状腺微小乳头状癌(papillary thyroid microcarcinoma,PTMC)术中冷冻切片病理诊断的要点,分析造成术中冷冻切片误诊、漏诊的原因。[方法]回顾性分析107例PTMC患者的病理学特征、冷冻切片和石蜡切片结果以及免疫组化结果。[结果]术中冷冻切片确诊97例,延迟诊断4例,误诊4例,漏诊2例。冷冻切片易出现毛玻璃样核及核内包涵体等人工假象。其中81例PTMC石蜡切片免疫组化法CK19、Galectin-3、TPO阳性率分别为93.8%、88.9%、13.6%。[结论]核增大、核轮廓不规则、核重叠、核沟是冷冻切片诊断PTMC的重要核参数改变,需结合组织结构异型性明确诊断。仔细剖检、强化取材及严格掌握诊断标准是避免误诊和漏诊,提高PTMC检出率的关键。
作者 陈椿林 张艳 孙峰 刘爱娥 陈荣建 顾新军
机构地区 上虞市人民医院 上虞市第二人民医院
出处 《肿瘤学杂志》 CAS 2013年第6期502-503,共2页 Journal of Chinese Oncology
关键词 甲状腺肿瘤 乳头状癌 微小癌 冷冻切片
分类号 R736.1 [医药卫生—肿瘤]
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二级参考文献27

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共引文献27

同被引文献23

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肿瘤学杂志
2013年 第6期

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