期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

颌下腺癌在多形性腺瘤中预后因素分析 被引量：4

Prognostic Factors of Carcinoma ex Pleomorphic Adenoma (CXPA) from Submandibular Gland
原文传递
导出
摘要 [目的]分析颌下腺起源的癌在多形性腺瘤中(CXPA)的预后及其影响因素,探讨其合理治疗。[方法]回顾性分析25例颌下腺起源的CXPA的临床及随访资料。所有患者均行原发灶根治性手术切除,8例接受了术后放疗。[结果]全组复发转移率为52.0%,5年总体生存率和肿瘤相关生存率分别为48.0%和53.9%。单因素分析结果显示病理分级、T分期、淋巴结转移和临床分期对颌下腺CXPA生存率的影响有统计学意义(P<0.05),侵袭性对生存率的影响接近有统计学意义(P=0.092)。COX多因素分析显示:淋巴结转移与颌下腺CXPA的生存率有关(P<0.05)。[结论]淋巴结转移是颌下腺CXPA的独立预后因素。根治性手术以及合理的术后放疗是其治疗的主要方法。 Purpose To investigate the prognostic influencing factors of carcinoma ex pleomorphic adenoma （CXPA） arisen from submandibular gland,and the reasonable treatment for it. Methods Clinical and following-up data of 25 cases with CXPA of submandibular gland were analyzed retrospectively All the cases underwent radical resection and in which 8 cases accepted postoperative radiotherapy. Results The overall recurrence was 52.0%,and 5-year overall survival and tumor-related survival were 48.0% and 53.9% respectively. Univariate analysis showed that histological grading,T staging,lymph node metastasis and clinical staging were prognostic influencing factors with statistical significance（P0.05）. Invasiveness seemed impacting on prognosis but without statistical significance（P=0.092）. COX multivariate analysis showed that lymph node metastasis had impact on CXPA’s survival（P0.05）. Conclusion Lymph node metastasis is an independent prognostic factor for CXPA of submandibular gland. Radical resection and reasonable postoperative radiotherapy are the predominant treatment methods.
作者 陈超 王佳峰 赵坚强 葛明华
机构地区 浙江省肿瘤医院
出处 《肿瘤学杂志》 CAS 2013年第6期461-465,共5页 Journal of Chinese Oncology
关键词 涎腺肿瘤 颌下腺 癌在多形性腺瘤中 预后 salivary gland neoplasms submandibular gland carcinoma ex pleomorphic adenoma prognosis
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1Thompson L. World Heahh Organization classification of tumours: pathology and genetics of head and neck tu- mours[J]. Ear Nose Throat J,2006,85(2): 74.
  • 2Gnepp DR. Malignant mixed tumors of the salivary glands: a review[J]. Pathol Annu, 1993,28(Pt 1): 279-328.
  • 3Antony J,Gopalan V,Smith RA,et al. Carcinoma ex pleo- morphic adenoma: a comprehensive review of clinical, pathological and molecular data [J]. Head Neck Pathol, 2012,6(1): 1-9.
  • 4Wahlberg P,Anderson H,Birklund A,et al. Carcinoma ofthe parotid and submandibular glands--a study of survival in 2465 patients[J]. Oral Oncol, 2002,38(7): 706-713.
  • 5Zbaren P,Zbaren S,Caversaccio MD,et al. Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome [J]. Otolaryngol Head Neck Surg,2008,138(5): 601-605.
  • 6胡宇华,李江,李蕾,傅涵冰.涎腺恶性多形性腺瘤161例临床病理分析[J].临床与实验病理学杂志,2007,23(1):43-47. 被引量：18
  • 7Lewis JE,Olsen KD,Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases[J]. Hum Pathol, 2001,32(6): 596-604.
  • 8Lfiers JC,Wittekindt C,Streppel M,et al. Carcinoma ex pleomorphic adenoma of the parotid gland. Study and im- plications for diagnostics and therapy [J]. Acta Oncol, 2009,48(1): 132-136.
  • 9Katabi N,Gomez D,Klimstra DS, et al. Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adeno- ma,with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases [J]. Hum Pathol, 2010,41(7): 927-934.
  • 10Chen AM,Garcia J,Bucci MK,et al. The role of postopera- tive radiation therapy in carcinoma ex pleomorphic adeno- ma of the parotid gland [J]. Int J Radiat Oncol Biol Phys, 2007,67(1): 138-143.

二级参考文献23

  • 1金晓龙,刘瑷如.83例涎腺恶性多形性腺瘤临床病理分析[J].上海口腔医学,1996,5(2):77-79. 被引量：4
  • 2李树玲.头颈肿瘤学[M].天津:天津科学技术出版社,1999,3.126-127.
  • 3LiVolsi V A,Perzin K H.Malignant mixed tumors arising in salivary glands.Ⅰ.Carcinomas arising in benign mixed tumors:a clinicopathologic study[J].Cancer,1977,39(5):2209-2230.
  • 4Gerughty R M,Scofield H H,Brown FM,et al.Malignant mixed tumors of salivary gland origin[J].Cancer,1969,24(3):471-486.
  • 5Moberger J G,and Eneroth C M.Malignant mixed tumors of the major salivary glands.Special reference to the histologic structure in metastases[J].Cancer,1968,21 (6):1198-1211.
  • 6Spiro R H,Koss L G,Hajdu S I,et al.Tumors of minor salivary origin,a clinicopathologic study of 492 cases[J].Cancer,1973,31(1):117-129.
  • 7Spiro R H,Huvos A G,Strong E W.Malignant mixed tumor of salivary origin,a clinicopathologic study of 146 cases[J].Cancer,1977,39(2):388-396.
  • 8Thackray A C,Sobin L H.Histological typing of salivary gland tumors[M]// International histological classification of tumors.Geneva:World Health Organisation,1972.
  • 9Seifert G,Sobin L H.The World Health Organisation's histological classification of salivary gland tumors.A commentary on the second edition[J].Cancer,1992,72(2):379-385.
  • 10Olsen K D,Lewis J E.Carcinoma ex pleomorphic adenoma,a clinicopathologic review[J].Head Neck,2001,23(9):705-712.

共引文献17

同被引文献26

  • 1曾婕,李彬,史季桐,孙宪丽,安裕志,李辽青,高飞.298例泪腺上皮性肿瘤临床特征及组织病理学分析[J].中国实用眼科杂志,2005,23(11):1164-1169. 被引量：9
  • 2胡宇华,李江,李蕾,傅涵冰.涎腺恶性多形性腺瘤161例临床病理分析[J].临床与实验病理学杂志,2007,23(1):43-47. 被引量：18
  • 3Barnes L,Eveson J W,Reichart P,et al.头颈部肿瘤病理学和遗传学[M] //刘红刚,高岩,主译.北京:人民卫生出版社,2006:245-328.
  • 4郑舟军,孙蕾娜,潘毅,孙保存.涎腺组织外恶性多形性腺瘤4例临床病理分析[J].中国肿瘤临床,2007,34(18):1065-1066. 被引量：1
  • 5Paulino A F G,Huvos A G.Epithelial tumors of the lacrimal glands:a clinicopathologic study[J].Ann Diagn Pathol,1999,3(4):199-204.
  • 6DeRosa G,Zeppa P,Tranfa F,et al.Acinic cell carcinoma arising in a lacrimal gland.First case report[J].Cancer,1986,57(10):1988-91.
  • 7Spiro R H,Huvos A G,Strong E W.Malignant mixed tumour of salivary orign:a clinicophologic study of 146 cases[J].Cancer,1977,39(2):388-96.
  • 8Olsen K D,Lewis J E.Carcinoma ex pleomorphic adenoma:a clinicopathologic review[J].Head Neck,2001,23(9):705-12.
  • 9Nagao K,Matsuzaki O,Saiga H,et al.Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland[J].Cancer,1981,48(1):113-21.
  • 10Ethunandan M,Witton R,Hoffman G,et al.Atypical features in pleomorphic adenomaa clinicopathologic study and implications for management[J].Int J Oral Maxillofac Surg,2006,35(7):608-12.

引证文献4

二级引证文献4

肿瘤学杂志
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部