摘要
[目的]观察丹参注射液对重症急性胰腺炎(SAP)患者的治疗作用及对血黏度的影响。[方法]2009年1月～2012年6月本院收治70例SAP患者随机分为2组,各35例。对照组患者给予常规支持性治疗;观察组在常规支持性治疗的基础上同时应用丹参注射液,40ml/d,静脉滴注,10d为一疗程。比较2组患者的临床症状消失时间,血和尿淀粉酶及白细胞计数恢复正常时间;治疗前及治疗10d测定2组患者的血黏度。[结果]观察组患者临床症状消失时间,血淀粉酶、尿淀粉酶及白细胞复常时间均较对照组显著缩短(P<0.01);治疗后2组患者全血高切黏度、全血中切黏度、全血低切黏度和血浆黏度均较治疗前显著降低(P<0.01),且观察组上述血黏度指标均较对照组显著降低(P<0.01)。[结论]丹参注射液辅助治疗SAP具有较好的疗效,其机制可能与降低血黏度而改善微循环有关。
[Objective]To explore the clinical efficacy of salvia miltiorrhiza injection in the treatment of severe acute pancreatitis,and to study its effect on the blood viscosity. [Methods]Seventy patients with se- vere acute pancreatitis, who visited our hospital in January 2009-June 2012, were randomly divided into Ob- servation Group and Control Group. There were 35 cases in each group. Cases in Control Group received routine supportive treatment, and cases in Observation Group received routine supportive treatment plus salvia miltiorrhiza injection 40ml/d for 10 day. Time of clinical symptoms disappearing, blood amylase re- covery, urine amylase recovery and leukocyte recovery was compared in both groups after treatment. Blood viscosity was determined in both groups before treatment and on 10th day after treatment. [-Results] Time of clinical symptoms disappearing, blood amylase recovery, urine amylase recovery and leukocyte recovery in Observation Group was significantly shortened than Control Group （P〈0.01）. Low shear viscosity,medi- um shear viscosity, and high shear viscosity of whole blood and plasma viscosity were significantly de- creased in both group after treatment, and the above-mentioned indictors of blood viscosity in Observation Group was significantly decreased than Control Group （P〈0. 01）. [Conclusion] Salvia miltiorrhiza injec-tion has preferable clinical efficacy in supplementary treatment of severe acute pancreatitis,and it is proba- bly related to improve microcirculation by decreasing blood viscosity.
出处
《中国中西医结合消化杂志》
CAS
2013年第6期296-298,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
胰腺炎
重症急性
丹参注射液
血黏度
severe acute pancreatitis
salvia miltiorrhiza injection
blood viscosity
