Total synthesis of (-)-isoaltholactone

Total synthesis of (-)-isoaltholactone

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摘要 A short and efficient stereoselective synthesis of a styryllactone (-)-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramolecular tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization. A short and efficient stereoselective synthesis of a styryllactone （-）-isoaltholactone has been achieved in seven steps and 33% overall yield, starting from the readily available carbohydrate D-mannose. The key steps of our synthesis involve intramolecu-lar tetrahydrofuran cyclization and one-pot acetonide deprotection-lactonization.

作者 LIU Jun ZHANG Xing LIU Yi BI JingJing DU YuGuo

机构地区 State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental Sciences School of Chemistry and Chemical Engineering

出处《Science China Chemistry》 SCIE EI CAS 2013年第7期928-932,共5页 中国科学（化学英文版）

基金 supported by the MOST of China (2012ZX09502001-001) the National Natural Science Foundation of China (2012CB822101,21072217 and 21202193)

关键词 total synthesis styryllactone isoaltholactone CARBOHYDRATE 全合成立体选择性合成碳水化合物 D-甘露糖四氢呋喃内酯类苯乙烯总收率

分类号 O621.3 [理学—有机化学]

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