摘要
目的:探讨前交叉韧带(anterior cruciate ligament,ACL)扩散张量成像(diffusion tensor imaging,DTI)与半定量传统磁共振(magnetic resonance imaging,MRI)测量方法的关联,阐明DTI应用于ACL的可行性及其特征。方法:健康志愿者31名行ACL常规MRI及DTI扫描。在常规MRI图像上测量矢状位ACL-胫骨角,冠状位ACL-胫骨角,Blumensaat线-ACL角,髁间窝顶倾角,ACL胫骨止点位置。采用DTI对ACL进行评定,将ACL平均分为5个区域(记为1st,2nd,3rd,4th,5th),分别测量各区域的各向异性值(fractional anisotropy,FA)值及表观扩散系数(apparent diffusion coefficient,ADC)值。并对ACL进行DTI测量的可重复性研究。结果:矢状位ACL-胫骨角、冠状位ACL-胫骨角、Blumensaat线-ACL角、髁间窝顶倾角、ACL胫骨止点位置分别为53.00°±2.46°,52.42°±5.15°,12.67°±5.71°,39.41°±2.64°,(24.90±2.84)%。ACL 1~5区(1st^5th)FA值分别为0.611±0.042,0.618±0.051,0.596±0.045,0.566±0.059,0.497±0.072;1~5区(1st^5th)ADC值分别为(1.068±0.216),(1.128±0.268),(1.189±0.197),(1.455±0.423),(1.779±0.384)×10–3mm2/s。矢状位ACL-胫骨角与2nd及3rd区域的相关系数分别为–0.568,–0.429,Blumensaat线-ACL角与1st及4th区域的相关系数分别为–0.507,–0.633,ACL胫骨止点位置与4th区域的相关系数为–0.593,均具有统计学意义(P<0.05)。ACL两组DTI重复资料的各区域FA值及ADC值之间的差异均不具有统计学意义(P>0.05),且具有明显相关性。结论:DTI能够定量地评价ACL的走行和连接,与ACL半定量MRI测量具有良好的对照,能够为临床医生提供关于ACL更加丰富的参考信息,对于下一步深入研究ACL病变诊治和大样本数据库的建立等具有一定的意义。
Objective： To measure anterior cruciate ligament （ACL） by diffusion tensor imaging （DTI）, combined with ACL half quantitative measurement magnetic resonance imaging （MRI） method as the contrast, and to preliminarily investigate the feasibility of DTI for ACL. Methods： The ACLs of 31 healthy volunteers were scanned with ordinary MRI and DTI. At ordinary MRI map, sagittal ACL-tibial angle, coronal ACL-tibial angle, Blumensaat line-ACL angle, angle of inclination of the intercondylar roof, and ACL-tibial insertion site were measured. As for DTI analysis of ACL, ACL was divide to 5 portions, namely 1^st, 2^nd, 3^rd, 4^th, 5^th, and all fractional anisotropy （FA） and apparent diffusion coefficient （ADC） values of every portion were recorded and repeated. Results： The sagittal ACL-tibial angle, coronal ACL-tibial angle, Blumensaat line-ACL angle, angle of inclination of the intercondylar roof, and ACL-tibial insertion site were 53.000±2.46°, 52.42°±5.15°, 12.67°±5.71°, 39.41 ±2.64, （24.90±2.84）%, respectively. FA values of different portions were 0.611±0.042, 0. 618±0.051, 0.596±0.045, 0.566±0.059, and 0.497±0.072. ADC values of 1^st-5^th portion were （1.068±0.216）, （1.128±0.268）, （1.189±0.197）, （1.455±0.423）, and （1.779±0.384）×10^-3 mm^2/s. The correlation coefficient of sagittal ACL-tibial angle and the FA value of 2^nd and 3^rd portion was -0.568 and -0.429. The correlation coefficient of Blumensaat line-ACL angle and the FA value of ist and 4^th portion was -0.507 and -0.633. The correlation coefficient of ACL-tibial insertion site and the FA value of 4^th portion was -0.593, all with statistical significance. FA and ADC values of all portions in both team＇s ACL didn＇t have significant difference （P〉0.05）, but had obvious correlation. Conclusion： DTI can be used to effectively evaluate the orientation and connection of ACL, having good contrast virtue with ACL half quantitative MRI measurement. It may provide more profound ACL information for clinicians, and it is of great significance for the further research and large sample data base of ACL pathology.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2013年第6期610-616,共7页
Journal of Central South University ：Medical Science
关键词
扩散张量成像
前交叉韧带
磁共振成像
各向异性
表观弥散系数
diffusion tensor imaging
anterior cruciate ligament
magnetic resonance imaging
anisotropy
apparent diffusion coefficient
