摘要
生物乙醇作为一种可再生的清洁能源,正在引起人们的广泛关注。酿酒酵母是乙醇生产中最常用的发酵菌株,但是乙醇耐受性往往成为限制酿酒酵母菌乙醇产量的重要因素。选育耐受高浓度乙醇的酵母菌株对于提高乙醇产率具有重要意义。然而传统的菌株改良方法具有育种周期长,突变方向不定等缺点。主要综述了近年来国内外对酿酒酵母菌耐受乙醇的分子生物学机理方面的研究成果,进而总结了提高酿酒酵母乙醇耐受性的基因工程、代谢工程。
Bioethanol as a renewable clean energy is causing widespread concern. Saccharomyces cerevisiae is the most commonly strains in the production of ethanol, but ethanol tolerance often become the most important factors that limit the Saccharomyces cerevisiae ethanol production. Improvement of ethanol tolerance of yeast cells is beneficial for ethanol production. However, traditional breeding methods have many shortcomings, such as long breeding cycle, variable mutation direction and so on. Recent research results about S. cerevisiae molecular mechanisms of tolerance to ethanol were reviewed, and the genetic engineering, metabolic engineering to improve S. cerevisiae ethanol tolerance was summarized.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2013年第6期105-110,共6页
China Biotechnology
关键词
酿酒酵母
乙醇耐受性
基因工程
Saccharomyces cerevisiae Ethanol tolerance Genetic engineering