摘要
近些年,具有抗肿瘤生物活性的人工合成多肽受到广泛的关注。尽管受技术条件的制约,目前多数抗肿瘤肽类药物的半衰期较短,但抗肿瘤肽类药物具有其独特的优势:它们分子量小、抗肿瘤特异性高、免疫原性低,并且易于合成和改造。目前,多种抗肿瘤肽及其衍生物已上市或进入临床研究,以肽为基础的治疗不仅高效低毒,还可以增加肿瘤对其他治疗方法的敏感度,对于肿瘤的临床治疗将具有重要价值。综述了诱发肿瘤坏死活性肽、细胞凋亡肽及功能阻断肽等几种新型天然抗肿瘤活性肽诱发肿瘤死亡的作用,并归纳其应用前景。
In recent years, increasing attention has been paid to synthetic antitumor peptides. Despite many technical hurdles, such as the half-life period of most peptides is short, peptides are advantageous because they are small, specific to tumor cells, possess low immunogenicity and are relatively easy to modify and design. Several antitumor peptides and their modified derivatives have advanced to clinical trials. Modem chemotherapy based on synthetic oligopeptides has the potential to provide an effective anti-tumor treatment for cancer patients while minimizing severe side-effects. Here, a review of the potential of novel natural anticancer peptides such as necrotic peptides, apoptotic peptides and function-blocking peptides in the context of their ability to induce tumor regression is presented. And the focus is on the therapeutic prospects of antitumor peptides and their possible application in tumor therapy.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2013年第6期93-98,共6页
China Biotechnology
基金
国家自然科学基金(31201061)
吉林省科技厅项目(20100944
20110729)资助项目
