摘要
目的研究铝镁加联合兰索拉唑在重型颅脑损伤并发应激性溃疡中的预防和治疗效果及相关的发病机理．为提高患者的治愈率提供依据。方法选择我院2009年5月～2012年8月入院接受治疗的90例重型颅脑损伤的患者作为研究对象，按照随机分组原则将所有患者分为铝镁加联合兰索拉唑组（治疗组）45例与兰索拉唑组（对照组）45例，人院后两组均积极接受颅脑外伤对症处理包括开颅手术，脱水，激素，冬眠低温等治疗，并每日给予兰索拉唑静脉滴注，治疗组在上述基础上给予预防性应用铝镁加混悬液，由胃管注入，每日3次。两组均治疗1个疗程即4周后，比较两组患者治疗前后神经损害严重程度（NNS）评分、格拉斯哥昏迷量表（GCS）评分以及应激性溃疡发生率。结果两组治疗前NNS、GCS评分结果差异无统计学意义，治疗1个疗程后，治疗组的NNS、GCS水平明显高于对照组，且治疗组的应激性溃疡发生率明显低于对照组，组间差异明显（P〈0．05）。结论对于重型颅脑损伤患者使用铝镁加联合兰索拉唑，对损伤后应激性溃疡具有较强的预防性作用，同时对颅脑损伤患者短期内行为学评价及神经功能评价具有明显改善，值得临床进一步推广使用。
Objective To study the prevention and treatment effect of Almagate joint Lansoprazole in heavy craniocere- bral injury complicated stress ulcer. Methods Selected from May 2009 to August 2012 in the hospital treated 90 cases of severe craniocerebral injury patients as the research object, as randomly grouping principle all patients were divid- ed into Almagate joint Lansoprazole group （treatment group） in 45 cases and Lansoprazole group 45 cases after admis- sion,two groups are actively accept craniocerebral trauma symptomatic treatment and daily to give Lansoprazole oral, treatment group was given the above basis the prophylactic use of aluminum and magnesium and suspension, daily use of 3 times. Two groups were treated 4 weeks later, compared the two groups nerve damage severity score, Glasgow coma scale score and stress ulcer incidence. Results The two groups before treatment nervous system damage serious score （NNS） and Glasgow coma scale （GCS） had no statistically significant, the treatment after a period of treatment, the two groups as NNS, GCS score comparison, the treatment group NNS level were higher than that of control group, and the treatment group of stress ulcer incidence was significantly lower than the control group, the difference was obviously between groups （P 〈 0.05）. Conclusion For patients with severe head injury use Almagate joint Lansopr azole after injury of stress ulcer has strong preventive action, at the same time for patients with craniocerebral injury in the short term behavior evaluation and neural function evaluation is obviously improved, and further promote the clinical use.
出处
《中国现代医生》
2013年第18期59-61,共3页
China Modern Doctor
基金
浙江省药学会医院药学科研专项基金(2012ZYY38)
关键词
铝镁加
兰索拉唑
重型颅脑损伤
应激性溃疡
Almagate
Lansoprazole
Severe traumatic brain injury
Stress ulcer
