摘要
H型高血压是伴有血浆同型半胱氨酸升高的原发性高血压,约占我国成年高血压患者的75%。H型高血压脑梗死的发生率较高,高血压患者血浆同型半胱氨酸水平升高是卒中复发和脑血管事件再发风险增加的独立危险因素。H型高血压的治疗应同时降低血压和血浆同型半胱氨酸的水平。目前的循证医学证据支持叶酸、维生素B12及依那普利叶酸片治疗H型高血压,并可能减少脑卒中的发生。本文就H型高血压与脑卒中相关性的研究进展进行综述。
H-type hypertension is described as primary hypertension with elevated serum homocysteine,accounting for 75%.The patients with H-type hypertension have higher incidence of cerebral infarction.Our findings suggest that elevated plasma homocysteine levels of ＂H＂ hypertension are associated with the increased risk of recurrent cerebrovascular disease and stroke recurrence.In Chinese hypertensive patients,lowering both blood pressure and plasma homocysteine level are recommended in H-type hypertension therapy.Evidence-based studies have confirmed the effect of folic acid and vitamin B12 and enalapril/folic on H-type hypertension.And it may reduce the risk of stroke. This review provides a broad overview of the progress of research in correlation between H-type hypertension and stroke.
出处
《中国医药科学》
2013年第11期43-44,92,共3页
China Medicine And Pharmacy
