摘要
目的研究七氟醚与瑞芬太尼静-吸复合全麻下老年患者维库溴铵的肌松效应。方法择期行腹腔镜胆囊切除术患者30例,ASAⅠ或Ⅱ级,按年龄分为老年组(65～80岁)和青年组(25～45岁),每组15例。七氟醚和瑞芬太尼诱导后,维持七氟醚呼气末浓度1.0MAC,瑞芬太尼0.05～0.1μg·kg-1·min-1持续输注。维持PETCO2 35～38mmHg。观察T1最大抑制时间(起效时间),T1恢复至25%的时间(T125%)、T1恢复至50%的时间(T150%)、恢复指数(RI)、TOFr(T4/T1)=0.7的时间。结果老年组起效时间、T125%、T150%、RI、TOFr(T4/T1)=0.7的时间均明显长于青年组(P<0.05)。结论老年患者吸入七氟醚全身麻醉中,适当减小维库溴铵的剂量即能达到满意的肌松效果,使患者术后肌力尽早恢复,提高老年患者围术期麻醉安全。
Objective To investigate neuromuscular blockade of vecuronium in elderly patients under sevoflurane-remifentanl anesthesia. Methods Thirty ASA I or II patients scheduled for laparoscopy cholecystectomy were randomly derided into group elder （65-80 years） and group youth （25-45 years）. Anesthesia was induced with sevoflurane, remifentanil and vecuroniurru Anesthesia was maintained with 1.0 MAC sevoflurane and remifentanil 0. 05-0.1 μg-kg 1. min 1. Per CO2 was maintained between 35-38 mm Hg. The onset time, T1 25% ,TI 50% recovery index,TOFr 0.7 were assessed. Results The onset time, T1 25%, T1 50%, RI, and TOFr（T4/T1）=0.7 were longer in group elder （P〈0.05）. Conclusion The need of vecuronium is decreased in sevoflurane anesthesia in aged patients, which may be beneficial for the patient＇s safety and recovery.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2013年第6期546-547,共2页
Journal of Clinical Anesthesiology
基金
广东省科技计划发展项目[(2010)1096]
