摘要
目的探讨大脑胶质瘤病(gliomatosis cerebri,GC)的分型及影像和病理学特征。方法对本院神经外科2010年3月至2012年11月间收治的13例GC进行分型对比研究。结果 GC的临床表现以头痛(8/13)和癫痫(3/13)常见。影像学检查显示弥漫性病灶累及大脑半球3个或3个以上脑叶及中枢结构,MRI呈长T1、长T2异常信号,增强扫描通常无强化,MRS也具有诊断价值。光镜和电镜结果显示肿瘤组织多以星形胶质细胞瘤多见(9例),也可为少突胶质细胞瘤(2例)。依据组织学表现,GC 1型以低级别星形胶质细胞瘤多见。结论可将GC分为两型,并且各具有不同的影像和病理学特征,1型GC以星形细胞瘤常见,临床上可依据分型的不同选择个体化的治疗方法。
Objective To evaluate the clinicopathologic and neuroimaging findings of GC and to compare the clinical findings between Type 1 and Type 2 GC. Methods Clinical comparison between subtypes and clinical analysis were performed. Results The clinical manifestions of these 13 patients included headache（ 8/13 ） and seizure（ 3/13 ）, Radiological examination revealed diffuse lesions infihative process involving more than three cerebral lobes, a diagnosis of MRS should be considered. Histologically, 13 cases of GC were classified into low and high grade histologic grades by cytologic anaplasia. Low-grade GC was more common in Type 1 than Type 2. Immunohistoehemical and Uhramierostructure results demonstrated that the infiltrating tumor cells were undifferentiated cells with astrocyt- ie or oligodendroglial differentiation. Conclusions Type 1 and 2 GC are somewhat different in neuroimaging and pathologic features. Type 1 GC were undifferentiated cells with astroeytic common. Treatment of GC was based on magnetic resonance imaging findings and histological confirmation for patients.
出处
《国际神经病学神经外科学杂志》
2013年第2期144-148,共5页
Journal of International Neurology and Neurosurgery
