摘要
在临床上肺移植、失血性休克、肺栓塞、体外循环、肺袖状切除手术等均会导致肺缺血再灌注损伤（IRI），IRI已成为肺移植术后重要的死因之一。进一步研究发生机制是解决肺IRI的重要环节。本文就肺IRI在分子生物学层面的作用机制：①炎症反应；②氧自由基；③蛋白酶；④脂类介质；⑤钙超载；⑥微循环障碍；⑦能量代谢障碍；⑧肺表面活性物质缺失等作一综述。
Clinically, lung transplantation, hemorrhagic shock, pulmonary embolism, extracorporeaI circulation,and lung sIeeve resection operation can cause pulmonary ischemia-reperfusion injury（IRI）, which has become one of the most important causes of death after lung transplantation. Further reaserch about mechanism is a significant process to solve the lung IRI. This article is to describe the pathogenesis of IRI in molecular biology level, including inflammatory reaction,oxygen free radical, proteinase, lipid mediators, calcium overload, microcirculatory disturbance, energy metabolic dysfunction, lung surface active material loss, and so on.
出处
《国际呼吸杂志》
2013年第12期941-944,共4页
International Journal of Respiration
关键词
缺血再灌注损伤
肺移植
发病机制
Ischemia-reperfusion injury
Lung transplantation
Pathogenesis
