摘要
由各种因素引起的肺动脉高压的根本问题是肺血管重构,但其发病机制尚未完全清楚。炎症反应在肺动脉高压的发病机制中扮演了重要角色已成为共识。近年来,应用多种抗炎药物疗法干预肺动脉高压取得了许多关键进展,为临床治疗提供了新的途径。本文拟就肺动脉高压发病过程中的免疫紊乱及抗炎药物治疗的l临床应用及研究现状进行综述。
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling of the pre-capillary pulmonary arteries. Although the exact pathophysiology remains unknown, there is increasing evidence to suggest an important role for inflammatory mechanism. Recently, many studies show that anti-inflammatory therapies have been effective in PAH, provide a new approach for PAH therapy. This article summarizes the mechanisms and anti-inflammatory therapy of PAH.
出处
《国际呼吸杂志》
2013年第12期931-934,共4页
International Journal of Respiration
基金
基金项目:国家自然科学基金(30971319)
江苏省2010年度普通高校研究生科研创新计划项目(CX10B-326Z)
关键词
肺动脉高压
炎症
抗炎治疗
Pulmonary arterial hypertension
Inflammation
Anti-inflammatory therapy