摘要
干扰素诱导蛋白10（interferon inducible protein10，IP-10）是CXC类趋化因子，其受体为CXCR3。IP-10在单核巨噬细胞、活化的成纤维细胞、内皮细胞、淋巴细胞等多种细胞表达。IP-10具有多种生物学功能，例如趋化炎症细胞，促进多种细胞释放炎症因子，抑制新血管生成，诱导细胞凋亡，抗病毒、抗肿瘤等作用。研究发现多种感染性肺疾病，如肺结核、严重急性呼吸综合征和高致病性禽流感等都会带来机体血清中IP-10含量的升高。近年研究表明IP-10基因转录调控在疾病的发生、发展中起关键作用，同时还可作为早期发现重症疾病的生物标记。本文围绕IP-10的基因结构、转录调控机制、生物学功能、与感染性肺疾病关系以及临床应用前景等几个方面作一简要介绍。
Interferon inducible protein 10 （IP-10） is a type of CXC chemokine, and its receptor is CXCR3. It has been eonfirmed to he expressed in a variety of cells, including mononuclears, macrophages, activated fibroblasts, endothelial cells, lymphocytes and so on. IP-10 is a pleiotropic molecule that has potent biological functions, such as promoting the ehemotactic activity of CXCR3＋ cells, inducing cell apoptosis, regulating cell growth,and defending virus and cancer. Recent researches have reported the increasing expression of IP 10 in many infectious lung diseases, such as tuberculosis, SARS,and highly pathogenic avian influenza. Recent studies show that the transcriptional regulation of IP-10 gene plays an important role in the occurrence and development of diseases, which can also be a biomarker for diagnosing diseases earlier. This article focuses on the structure, transcriptional regulation, and biological functions of IP-10 gene, the relevance between IP 10 gene and infectious lung diseases, and its prospect in the clinical application.
出处
《国际呼吸杂志》
2013年第12期918-923,共6页
International Journal of Respiration
基金
基金项目：广东省自然科学基金（S2011010003917）
关键词
干扰素诱导蛋白10
感染性肺疾病
研究进展
Interferon inducible protein 10
Infectious lung diseases
Research progress
