摘要
目的探讨检测血浆抗凝血酶Ⅲ(AT-Ⅲ)活性、D-二聚体(DD)水平和血小板(PLT)数量在儿童脓毒症中的临床价值。方法选取儿科重症监护病房住院患儿103例,其中普通感染组30例,脓毒症组73例;另选择30例健康儿童为正常对照组。检测并比较血浆AT-Ⅲ活性、DD水平和PLT数量。结果与正常对照组和普通感染组比较,脓毒症组AT-Ⅲ活性和PLT数量明显降低,DD水平明显升高,差异有统计学意义(P均<0.01);而正常对照组和普通感染组间三项指标的差异无统计学意义(P均>0.05);脓毒症患儿中严重脓毒症组、DIC组和死亡组的AT-Ⅲ活性和PLT数量明显降低,DD水平明显升高,差异有统计学意义(P均<0.01),DIC组三项指标同时异常的发生率为70.37%。结论儿童脓毒症存在明显的凝血纤溶功能紊乱,血浆AT-Ⅲ活性、DD水平和PLT数量检测有助于儿童脓毒症时DIC的早期诊断,并且对患儿的病情估计和预后判断有一定的临床价值。[临床儿科杂志,2013,31(6)
Objectives To study the clinical value of antithrombin-Ⅲ （AT-Ⅲ）, D-dimer （DD） and platelet （PLT） in children with sepsis. Methods One hundred and three children in pediatric intensive care unit were divided into ordinary infection group （n=30） and sepsis group （n=73）, and 30 healthy children were selected as control group. Plasma AT-Ⅲ activ- ity, DD level and PLT count were detected. Results Compared with control group and ordinary infection group, AT-Ⅲ ac- tivity and PLT count were both significantly lower （P〈0.01） and DD level was significantly higher （P〈0.01） in sepsis group. The differences of the three parameters were not significant between control group and ordinary infection group. However, AT-Ⅲ activity and PLT count were both significantly lower （P〈0.05） and DD level was significantly higher （P〈0.01） in se-vere sepsis group, disseminated intravascular coagulation （DIC） group and death group. The abnormal rate of all the three parameters was 70.37% in DIC group. Conclusions Children with sepsis have obvious dysfunction of coagulation and fibri-nolysis system. The activity of AT-Ⅲ, DD level and PLT count are helpful for the early diagnosis of DIC in children with sepsis, and can also be valuable in the evaluation of severity and prognosis.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2013年第6期530-532,共3页
Journal of Clinical Pediatrics
