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依库珠单抗治疗补体调节异常性肾脏病研究进展 被引量：2

A review of eculizumab on the treatment of complement-related kidney disease
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摘要 补体系统异常活化在许多疾病的发生及发展过程中占据重要地位,肾脏尤其容易受累。文章介绍抗补体C5单克隆抗体依库珠单抗在补体调节异常性肾脏病治疗中的研究进展。 Abstract： The abnormal activation of complement system plays an important role in the pathogenesis and development of many diseases and the kidney is especially easy to be involved. In this review, the clinical effect of eculizumab, a humanized monoclonal anti-C5 antibody, on complement-related kidney disease will be discussed.
作者 周建华 周艳梅
机构地区 华中科技大学同济医学院附属同济医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2013年第6期501-504,共4页 Journal of Clinical Pediatrics
关键词 依库珠单抗 补体 肾脏病 治疗 eculizumab complement kidney disease treatment
分类号 R726.9 [医药卫生—儿科]
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参考文献35

  • 1Botto M, Kirschfink M, Macor P, et al. Complement in hu- man diseases., lessons from complement deficiencies [J]. Mol Immunol, 2009, 46(14): 2774-2783.
  • 2Schmidtko J, Peine S, EL-Housseini Y, et al. Treatment of atypical hemolytic uremic syndrome and thrombotic microan- giopathies., a focus on eculizumab [J]. Am J Kidney Dis, 2013, 61(2):289-299.
  • 3McRae JL, Duthy TG, Griggs KM, et al. Human factor H- related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein [J]. J Immunol, 2005, 174(10):6250-6256.
  • 4Constantinescu AR, Bitzan M, Weiss LS, et al. Non- enteropathic hemolytic uremic syndrome:causes and short- term course [J]. Am J Kidney Dis, 2004,43(6): 976-982.
  • 5Campistol JM, Arias M, Ariceta G, et al. An update for atypical haemolytic uraemic syndrome: diagnosis and treat- ment. A consensus document [J]. Nefrologia, 2013,33 (1): 27-45.
  • 6Noris M, Caprioli J, Bresin E, et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype [J]. Clin J Am Soc Nephrol, 2010,5(10): 1844-1859.
  • 7Westra D, Volokhina E, van der Heijden E, et al. Genetic disorders in complement (regulating) genes in patients with atypical haemolytic uraemic syndrome (aHUS) [J]. Nephrol Dial Transplant, 2010, 25(7): 2195-2202.
  • 8Bienaime F, Dragon-Durey MA, Regnier CH, et al. Muta- tions in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome [J]. Kidney Int, 2010, 77(4): 339-349.
  • 9Dragon-Durey MA, Sethi SK, Bagga A, et aL Clinical fea- tures of anti-factor H autoantibody-associated hemolytic ure- mic syndrome [J]. JAm Soc Nephrol,2010,21(12):2180-2187.
  • 10Orth D, W0rzner R. Complement in typical hemolytic uremic syndrome [J]. Semin Thromb Hemost, 2010, 36(6): 620-624.

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临床儿科杂志
2013年 第6期

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