摘要
目的 探讨新生儿窒息脐血一氧化氮 (NO)及血糖的变化。方法 对 30例窒息新生儿脐血NO和血糖水平进行检测 ,并与 32例正常新生儿比较。结果 窒息组的脐血NO-2 (43.74± 13.2 0 μmol·L-1)、血糖 (5 .6 3± 1.2 0mmol·L-1)明显高于对照组脐血NO-2 (2 7.2 8± 9.5 2 μmol·L-1)和血糖 (3.6 5± 0 .79mmol·L-1) (P <0 .0 1) ;重度窒息组脐血NO-2 (6 0 .17± 9.93μmol·L-1)和血糖 (7.2 5± 0 .5 4mmol·L-1)显著高于轻度窒息组 (36 .72± 6 .33μmol·L-1和 4.93± 0 .5 3mmol·L-1) (P <0 .0 1) ;NO和血糖水平呈显著正相关 ,而且脐血NO水平与新生儿缺氧缺血性脑病密切相关。
Objective To investigate the changes of nitric oxide (NO)and glucose in cord blood in newborns with asphyxia . Methods The levels of NO and glucose in cord blood were determined in 30 newborns with asphyxia,and 32 healthy neonates. Results The levels of NO - 2 and glucose in cord blood were 27.28±9.52μmol·L -1 and 3.65±0.79mmol·L -1 respectively in the control group,and 43.74±13.20μmol·L -1 and 5.65±1.20mmol·L -1 in the asphyxia group.The levels of NO - 2 and glucose levels in cord blood in the newborns with asphyxia were much higher than those in the normal controls.The levels of NO - 2 and glucose levels in cord blood in the newborns with severe asphyxia(60.17±9.93μmol·L -1 and 7.25±0.54mmol·L -1 )were found to be significantly higher than those seen in the light asphyxia group(36.72±6.33μmol·L -1 and 4.93±0.53mmol·L -1 ,P<0.01).The NO levels were significantly related to the glucose levels.Moreover,the cord blood No level was related closely to development of hypoxia-ischemic encephalopathy. Conclusion The determinations of NO and glucose in cord blood in newborns with asphyxia have important clinical significance.
出处
《新乡医学院学报》
CAS
2000年第1期24-26,共3页
Journal of Xinxiang Medical University
基金
河南省教委资助项目!(96320033)
关键词
新生儿窒息
脐血
一氧化氮
血糖
预后
asphyxia
neonatorum
cord blood
nitric oxide
glucose
hypoxia-ischemic encephalopathy ischemia
