摘要
目的：探讨多巴胺Ｄ３受体（ＤＲＤ３）基因多态性与帕金森病（ｐａｒｋｉｎｓｏｎ ｄｉｓｅａｓｅ，ＰＤ）遗传易感性的关系。方法：采用聚合酶链反应－限制性片段长度多态性（ＰＣＲ－ＲＦＬＰ）技术分析比较了１３０例ＰＤ病人和 １２０名正常对照者的 ＤＲ Ｄ３基因第 １号外显子 ＢａｌＩ多态性和第 ５号内含子 ＭｓｐＩ多态性。结果： ＤＲ Ｄ３基因 ＢａｌＩ多态位点和ＭｓｐＩ多态位点各基因型的分布和等位基因频率在ＰＤ组和对照组间差异均无显著意义（均Ｐ＞０．０５）。结论：ＤＲＤ３基因 ＢａｌＩ和 ＭｓｐＩ多态性与 ＰＤ的遗传易感性无关。
AIM: To explore the association between genetic polymorphisms of dopamine D3 receptor (DR D3) gene and susceptibility to parkinson disease (PD). METHODS: The polymorphisms of DR D3 gene BalI and MspI which are in the exon 1 and intron 5, respectively, were analyzeds in 130 PD patients and 120 unrelated healthy controls with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: For the two polymorphic loci we studied, no statistical differences were found in the allelic frequencies or genotypic distribution between the control and PD Patients (P > 0. 05). CONCLUSION: Our findings don' t support the hypothesis that susceptibility to PD is associated with the DR D3 gene polymorphisms examined in our population.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第2期108-110,共3页
Chinese Journal of New Drugs and Clinical Remedies
基金
卫生部临床学科重点项目基金资助!(97040229)
关键词
震颤性麻痹
多巴胺D3受体
基因多态性
parkinson disease
dopamine D3 receptors
genes
polymorphism (genetics)
