摘要
目的 观察常温下门静脉阻断再通后对肝脏、肠道的影响 ,明确有无细菌移位及与阻断时间的关系。方法 家兔40只随机分为 4组 ,分别阻断门静脉 0min(A组 )、15min(B组 )、30min(C组 )、45min(D组 )。 6h后取肠系膜淋巴结、下腔静脉血作细菌培养 ,同时测定肝肾功能 ,并观察肝脏、空肠、回肠组织形态学变化。结果 B、C、D组肝脏、肠粘膜结构及肝功能与A组相比均有不同程度损伤。阻断 30min以上组 (C、D组 )除上述指标变化明显外 ,细菌移位率亦较A组显著增高。肾功能各组间无差异。结论 常温下门静脉阻断再通可致肝脏、肠道粘膜损伤 ,并促发细菌移位 ,其程度随阻断时间延长而加重。
Objective To investigate the effect on liver and gut after blocking portal vein at normothermia temporarily and the relation between the portal occlusion and gut-bacterial translocation time. Methods 40 rabbits were allocated into four groups. The portal vein was clamped for 0 mi n, 15 min, 30 min, and 45 min respectively in different group. Six hours later, the mesenteric lymph nodes and vena cava blood were harvested for bacteriologica l culture. Liver and renal functions were also determined. In addition, morpholo gy changes of liver, jejunum, and ileum were analyzed. Results The st ructure of liver and intestinal mucosa and the function of liver in blocking gro ups were diversely damaged than the control group. The groups which subjected to blocking portal vein up to 30 min not only showed the much alterations mentione d above but also displayed the significant increase of bacterial translocation. There were no statistically significant difference in renal function among four groups. Conclusion Liver and intestinal mucosa damage and bacterial translocation occurred after temporary blocking portal vein at normothermia, the degree of those changes became more serious with prolonging occlusion time.\;
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
2000年第5期356-358,共3页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省卫生厅科研基金资助项目!(No940 2 )
关键词
门静脉阻断
细菌移位
肠粘膜
胰十二指肠切除术
portal vein blocking
bacterial translocation
liver
inte stinal mucosa
pancreaticoduodenectomy
animals, laboratory
