摘要
目的探讨伤寒菌株耐药谱及当地诊所使用的 7个厂家 12个批号治疗用药氟哌酸的疗效。方法应用琼脂扩散法 ,对 5株伤寒杆菌用 12种抗菌素及氟哌酸胶囊自制的纸片进行药敏测定。结果本次流行中分离的菌株具有多重耐药 ,对氯霉素、羧苄青霉素、氨苄青霉素耐药 ,对氟哌酸、庆大霉素、丁胺卡拉、头孢三嗪、头孢克罗敏感。在 12个批号的氟哌酸中 ,有 3个批号的氟哌酸与标准氟哌酸纸片两者的抑菌环大小有明显差异。结论 1998年贵州省威宁县爆发流行中所分离的伤寒菌具有多重耐药性。规范药品进货渠道保证药品质量至关重要。
Objective To study the drug resistance of typhoid salmonella and the efficacy of norfloxacin in 12 Lot NO.s produced by 7 factories. Methods 5 strains of typhoid were tested with the drug resistance test paper made out of those norfloxacin and 12 kinds of antibiotic by kirby Bauer method. Results The strain seperated in this epidemic was of multiple drug resistance.Which is completely drug-resistive to choloramphenicl,carbenicillin,ampicillin and sensitive to norfloxacin,gentamicin,amikacin,cefatrizine,cefaclor capsules.There was sharp difference in averige diameter of the bacteriostatic ring between the test paper made out of the norflorxacin in 3 Lot NO.s and those purchased.Conclusion[WT5”BZ] Multiple drug resistance in the strain seperated in a fulminant epidemic of typhoid in Weining county of Guizhou province in 1998.The normal purchasing and the quality of the drug are extremely important.
出处
《贵州医药》
CAS
2000年第9期527-528,共2页
Guizhou Medical Journal
