摘要
背景:免疫相关性全血细胞减少涉及多个临床学科,近年来受到高度重视。骨髓造血早期细胞自身抗体及免疫调节功能可能是其症结所在。目的:分析骨髓造血早期(干/祖)细胞自身抗体在免疫相关性全血细胞减少症发病机制中的作用及其进展。方法:由作者电子检索1992年3月至2012年3月PubMed、万方医学网以及CHKD数据库中关于骨髓造血细胞相关抗体的文章,中文检索词为"免疫相关性全血细胞减少症、骨髓造血细胞、自身抗体、辅助性T细胞17",英文检索词为"Immunorelated pancytopenia,Bone marrow hematopoietic cells,Autoantibody,Th17cells"。排除重复性研究共保留30篇进行总结分析。结果与结论:骨髓造血细胞自身抗体是由于T淋巴细胞调控失衡,导致B淋巴细胞及其亚群数量和功能异常而产生的一类抗体。它破坏或抑制骨髓早期造血细胞成熟分化,最终引起外周血细胞减少而致病。T辅助细胞17细胞数量增多、功能亢进可能与免疫相关性全血细胞减少症患者自身抗体产生呈一定相关性,是免疫相关性全血细胞减少症发病的重要因素。
BACKGROUND：mmunorelated pancytopenia involves in multiple clinical disciplines and has been paid more and more attention in recent years. Autoantibodies on bone marrow hematopoietic stem cel s and immune regulation function may be the crux of the problem. OBJECTIVE：To study the progress on the role of bone marrow hematopoietic stem cel-associated antibodies in the pathogenesis of immunorelated pancytopenia. METHODS：A computer retrieval of PubMed, WangFang Med Online and CHKD database was conducted for articles regarding the autoantibodies on bone marrow hematopoietic stem cel s published from March 1992 to March 2012. The keywords were＂immunorelated pancytopenia, bone marrow hematopoietic cel s, autoantibody, T helper 17 cel s＂. Repetitive articles were excluded, and final y 30 articles were included in result analysis. RESULTS AND CONCLUSION：The production of autoantibodies on bone marrow hematopoietic cel s is due to the imbalance in T lymphocyte regulation resulting in abnormal quantity and function of B lymphocyte and its subset. They destroyed or inhibited the differentiation and maturation of bone marrow hematopoietic cel s, leading to a reduction of peripheral blood cel s eventual y. The increasing number of T helper 17 cel s and the hyperfunction of T helper 17 cel s may be associated with the production of autoantibodies in patients with immunorelated pancytopenia, which is an important factor for the pathogenesis of immunorelated pancytopenia.
出处
《中国组织工程研究》
CAS
CSCD
2013年第19期3603-3610,共8页
Chinese Journal of Tissue Engineering Research
基金
云南省内设研究机构专项基金资助项目(2010NC002)
云南省教育厅科学研究基金资助项目(2012J092)~~
